AI Article Synopsis
- Pediatric blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare and aggressive blood cancer in children with poor treatment outcomes.
- Recent studies show that bone marrow transplantation (BMT) after high-intensity treatment can improve survival rates in adults with this condition.
- A case study of a 9-year-old girl successfully treated with chemotherapy followed by BMT using a gentler approach called reduced intensity conditioning (RIC) indicates that this method may be a viable treatment option for pediatric patients with BPDCN.
Article Abstract
Pediatric blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare hematological malignancy that has an extremely poor prognosis despite the use of intensive chemotherapy. Recently, treatment of BPDCN with bone marrow transplantation (BMT) using myeloablative conditioning has been reported to increase survival in adults. We report a 9-year-old girl with cutaneous BPDCN who was successfully treated with combination chemotherapy followed by BMT using reduced intensity conditioning (RIC), without any adverse complications. The success of this treatment regimen suggests that BMT with RIC may be a feasible option for treating children with cutaneous BPDCN.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4925505 | PMC |
| http://dx.doi.org/10.1007/s12288-015-0543-0 | DOI Listing |
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