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Objective: The primary goal of this study was to establish the current microbial trends in vertebral osteomyelitis/discitis (VOD) amid the opioid epidemic and to determine if intravenous drug use (IVDU) predisposes one to a unique microbial profile of infection.

Methods: The authors performed a retrospective cohort study consisting of 1175 adult patients diagnosed with VOD between 2011 and 2022 at a single quaternary center. Data were acquired through retrospective chart review, with pertinent demographic and clinical information collected.

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Article Synopsis
  • Spondylodiscitis is an infectious disease affecting the spine that often arises from another infection source, prompting a study to investigate differences in bacterial patterns and resistance in two types of hospitals in Germany.
  • The research included 135 patients, finding that most presented with pain and some showed neurological deficits, with key bacteria identified varying between a university hospital (UVH) and a non-university hospital (NUH).
  • The study revealed higher rates of antibiotic-resistant bacteria and more patients with malignancies at the UVH, highlighting the need for tailored treatment approaches based on regional bacterial profiles and the presence of additional health risks.
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Article Synopsis
  • Infantile spondylodiscitis is a rare but serious condition that can lead to complications like spinal deformities if not diagnosed and treated early.
  • This case study discusses a 21-month-old girl who experienced difficulty walking and constipation due to spondylodiscitis after a skin burn, initially diagnosed via MRI after inconclusive initial tests.
  • The report emphasizes the need for quick diagnosis and treatment, especially with antibiotics when infections aren't easily identifiable, to prevent neurological complications in young patients.
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Introduction And Importance: Brucellosis, the most common microbial zoonotic disease in the world, is endemic in both industrialized and underdeveloped countries. Between 2 and 53% of patients with brucellosis, patients develop spondylitis, and people between the ages of 50 and 60 are the most commonly affected. It mostly affects the lumbar vertebrae (L4 and L5 in particular) and the thoracic vertebrae.

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is a non-tuberculous mycobacterium (NTM) that sporadically causes infections in humans and can cause rare bone and joint infections in immunocompromised hosts with history of spinal surgery. This slow-growing mycobacterium takes 8-12 weeks to grow on culture. Metagenomic next-generation sequencing (MNGS) is a highly sensitive and specific plasma-based microbial cell-free DNA test that can detect weeks prior to culture growth.

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