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Genetic heterogeneity of platelet glycoproteins Ia and IIIa and the risk of spontaneous miscarriages. | LitMetric
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Genetic heterogeneity of platelet glycoproteins Ia and IIIa and the risk of spontaneous miscarriages.

Nikolaos Vlachadis Vasileios Tsamadias Nikolaos Vrachnis Georgios Kaparos Nikolaos Vitoratos Evaggelia Kouskouni Emmanuel Economou

J Matern Fetal Neonatal Med

a Clinical Laboratory of Therapeutic Individualization, Second Department of Obstetrics and Gynecology, National and Kapodistrian University of Athens, School of Medicine, Aretaieio Hospital, Athens , Greece.

Published: June 2017

AI Article Synopsis

  • The study explored how genetic variations in platelet proteins (GpIa-C807T and GpIIIa-PlA1/PlA2) relate to the risk of spontaneous abortions in women.
  • Researchers compared 222 women with unexplained miscarriages to 60 fertile women and found that specific genetic variants increased the risk of fetal loss significantly, especially in younger patients.
  • The findings suggest that these genetic markers could be potential risk factors for miscarriage in the Greek population, particularly for those under 30 years old.

Article Abstract

Objective: The aim of this study was to investigate the association between the genetic heterogeneity of platelet glycoproteins Ia (GpIa-C807T) and IIIa (GpIIIa-PlA1/PlA2) and spontaneous abortions.

Study Design: Two hundred and twenty two women with a history of unexplained spontaneous miscarriages and no successful pregnancy, and 60 fertile women serving as controls were genotyped for the GpIa-C807T and GpIIIa-PlA1/PlA2 polymorphisms by pyrosequencing.

Results: In comparison with the common alleles homozygotes, GpIa-807T and GpIIIa-PlA2 carriers had an increased risk of fetal loss (OR = 3.36, 95%CI: 1.85-6.11, p < 0.001, and OR = 2.58, 95%CI: 1.30-5.13, p = 0.006, respectively). For subjects who were combined carriers of the GpIa-807T and GpIIIa-PlA2 alleles, the risk increased further (OR = 9.13, 95%CI: 2.99-27.82, p < 0.001). The above ORs were highest for women who were younger than 30 years of age.

Conclusions: The GpIa-C807T and GpIIIa-PlA1/PlA2 polymorphisms and more pronouncedly their combination are associated with increased risk of spontaneous abortions. The correlations were stronger for younger patients. Our results indicate that GpIa-807T and GpIIIa-PlA2 are susceptibility alleles for fetal loss in the Greek population.

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 Source
http://dx.doi.org/10.1080/14767058.2016.1212330DOI Listing

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