Antifungal Amide Alkaloids from the Aerial Parts of Piper flaviflorum and Piper sarmentosum.

Sixty-three amide alkaloids, including three new, piperflaviflorine A (), piperflaviflorine B (), and sarmentamide D (), and two previously synthesized ones, (1,3)-1-cinnamoyl-3- hydroxypyrrolidine () and -[7'-(4'-methoxyphenyl)ethyl]-2-methoxybenzamide (), were isolated from the aerial parts of and Their structures were elucidated by detailed spectroscopic analysis and, in case of , by single-crystal X-ray diffraction. Most of the isolates were tested for their antifungal and antibacterial activities. Ten amides (-) showed antifungal activity against ATCC 90 113 with IC values in the range between 4.7 and 20.0 µg/mL.