Proliferating trichilemmal tumors (PTTs) are benign adnexal skin neoplasms that arise from the outer root sheath of the hair follicle. These tumors are most commonly observed on the scalp and occur, most of the time, in elderly women. Malignant transformation of these neoplasms is a rare event; less than 50 cases have been reported in the English medical literature. We present the case of a 39-year-old Hispanic woman with a tumor located on the skin of one of her breasts that in her third surgical procedure the histologic examination revealed the presence of a malignant proliferating trichilemmal tumor (MPTT). Furthermore, a review of the medical literature and a discussion of the clinical and pathologic features of this rare entity are provided.
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http://dx.doi.org/10.1155/2016/7481569 | DOI Listing |
Dermatopathology (Basel)
December 2024
Department of Pathology & Immunology, Baylor College of Medicine, Houston, TX 77030, USA.
Malignant proliferating trichilemmal tumors (MPTTs), arising from the external root sheath of hair follicles, are exceptionally rare, with limited documentation of their genetic alterations. We present a case of a 64-year-old African American woman who initially presented with a gradually enlarging nodule on her posterior scalp. An initial biopsy at an outside hospital suggested metastatic adenocarcinoma or squamous cell carcinoma (SCC) of an uncertain origin.
View Article and Find Full Text PDFCureus
November 2024
Department of Surgery, Ng Teng Fong General Hospital, Singapore, SGP.
Trichilemmal cysts, also known as pilar cysts, are commonly found on hair-bearing surfaces, such as the scalp or hairline. These are cysts that form from hair follicles and are benign. We describe an unusual case of a middle-aged lady presenting with a longstanding left-sided inframammary mass that had started growing more in the last year prior to the presentation.
View Article and Find Full Text PDFCureus
November 2024
General Surgery, Malavya Hospital, Bengaluru, IND.
A 54-year-old male with a past history of acute pancreatitis and pulmonary embolism presented with a scalp tumor in the occipital region for a six-month duration. With a biopsy report of squamous cell carcinoma, wide local excision with the lower island trapezius myocutaneous flap with skin grafting was done. However, the final pathology report revealed a proliferating trichilemmal tumor with clear margins.
View Article and Find Full Text PDFJ Surg Oncol
November 2024
Department of Surgery, MercyOne Medical Center, Des Moines, Iowa, USA.
Malignant proliferating trichilemmal tumors (MPTT) are rare skin lesions arising from the outer sheath of the hair follicle root. Because of their rarity and difficulty in pathologic identification, these skin lesions are often initially misdiagnosed. After a literature review, we found initial clinical or histopathological misdiagnosis has an associated 10.
View Article and Find Full Text PDFPhotodiagnosis Photodyn Ther
October 2023
Department of Phototherapy at Shanghai Skin Disease Hospital, School of Medicine, Tongji University, Shanghai, 200443, China. Electronic address:
Wide local excision with a 1cm margin is the standard treatment for proliferating trichilemmal tumor (PTT), but it is challenging to treat giant tumors, or tumors located on the scalp and face. We present a case of a 90-year-old woman with painful PTT on the cheek who was cured by a combination of limited resection and neoadjuvant ALA-PDT. Preoperative and postoperative 20% ALA-PDT was used for a total of 6 sessions.
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