Ethnopharmacological Relevance: Zao-Jiao-Ci (ZJC), as the spine of Chinese Honey locust (Gleditsia sinensis Lam.), is traditionally used as Chinese medicine to reduce inflammation.
Aim Of The Study: The present study aimed to investigate an anti-inflammatory effect of ZJC aqueous extract both in vitro and in vivo, as well as its underlying mechanisms.
Materials And Methods: Anti-inflammatory effect of ZJC aqueous extract was evaluated by using carrageenan-induced paw edema in rats. In addition, the inhibitory effects of ZJC on nitric oxide production, intracellular reactive oxygen species production, pro-inflammatory mediator expression and prostaglandin E (PGE) production were determined by using LPS-activated RAW 264.7 cells. The anti-oxidant activity of ZJC was assessed using 2,2'-azino-bis-3-ethylbenzthiazoline-6-sulfonic acid assay.
Results: ZJC aqueous extract showed significant suppressive effect on paw edema in rats at 100mg/kg. Moreover, ZJC aqueous extract decreased the expression of cyclooxygenase (COX)-2 and significantly decreased the PGE2, tumor necrosis factor-α, interleukin (IL)-1β and IL-6 production in LPS-activated macrophages in dose-dependent manners. ZJC aqueous extract inhibited the mRNA expression of these inflammatory cytokines as well. Furthermore, ZJC aqueous extract was found as an anti-oxidant and could inhibit ROS production in the LPS-induced cells.
Conclusions: These findings show the potential of ZJC aqueous extract as a naturally occurring COX-2 inhibitor to reduce inflammation.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.jep.2016.07.020 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Chrysanthemum extract mitigates high-fat diet-induced inflammation, intestinal barrier damage and gut microbiota disorder.
Food Funct
January 2025
Institute of Food Nutrition and Quality Safety, College of Life Sciences, China Jiliang University, Hangzhou, Zhejiang, 310018, China.
An effective intervention for obesity without side effects is needed. Chrysanthemum may be the preferred choice due to its influence in the improvement of glycolipid metabolism. This study assessed the efficacy of chrysanthemum and its flavonoids in mitigating high-fat diet (HFD) induced obesity, focusing on the integrity of the intestinal barrier, inflammation, and gut microbiota.
View Article and Find Full Text PDFStabilization of blackberry extract by interaction with bovine sodium caseinate in the presence of tara gum.
J Sci Food Agric
January 2025
Laboratorio de Investigación, Desarrollo y Evaluación de Alimentos (LIDEA), Facultad de Ciencias Bioquímicas y Farmacéuticas, Universidad Nacional de Rosario (UNR), Santa Fe, Argentina.
Background: The antioxidant capacity of anthocyanins (AC) rapidly degrades during storage, highlighting the need for their stabilization. The conformational properties and high proline content of sodium caseinate (NaCAS), combined with the formation of NaCAS microgels in the presence of tara gum (TG) and acid gelation, suggest its potential as an effective stabilizing or encapsulating agent of AC.
Results: Spectrofluorimetric results suggest the formation of a complex between NaCAS and AC.
Experimental study on the simultaneous effect of smart water and clay particles on the stability of asphaltene molecule and emulsion phase.
Sci Rep
January 2025
Department of Petroleum Engineering, Faculty of Chemical Engineering, Tarbiat Modares University, Tehran, Iran.
Enhancing oil recovery in sandstone reservoirs, particularly through smart water flooding, is an appealing area of research that has been thoroughly documented. However, few studies have examined the formation of water-in-heavy oil emulsion because of the incompatibility between the injected water-folded ions, clay particles, and heavy fraction in the oil phase. In this study, we investigated the synergistic roles of asphaltene and clay in the smart water flooding process using a novel experimental approach.
View Article and Find Full Text PDFComputational Analyses of Alkaloids as Green Corrosion Inhibitors on Fe(110).
Langmuir
January 2025
Department of Physics, K. N. Toosi University of Technology, Tehran 19697, Iran.
One of the successful techniques developed for the inhibition of metal corrosion is the utilization of phytochemicals from plant extracts as corrosion inhibitors. Theoretical studies are utilized to predict how organic components behave on metal surfaces and can pave the way for the development and synthesis of innovative, efficient corrosion inhibitors. However, atomic-level insights into the inhibition mechanisms of these green components are still needed.
View Article and Find Full Text PDFAntioxidant and anti-inflammatory function of walnut green husk aqueous extract (WNGH-AE) on human hepatocellular carcinoma cells (HepG2) treated with t-BHP.
PLoS One
January 2025
Institute of Natural Antioxidants and Anti-Inflammation, Dali University, Dali, Yunnan, China.
Oxidative damage, oxidative inflammation, and a range of downstream diseases represent significant threats to human health. The application of natural antioxidants and anti-inflammatory agents can help prevent and mitigate these associated diseases. In this study, we aimed to investigate the effectiveness of walnut green husk (WNGH) as an antioxidant and anti-inflammatory agent in an in vitro setting.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!