AI Article Synopsis
- Intraocular iris rhabdomyosarcoma is extremely rare, typically reported as a primary tumor, and this case highlights its occurrence as a metastasis from a foot tumor.
- An 18-year-old female had a rhabdomyosarcoma in her foot that spread to her iris, prompting referral for treatment after a partial remission and signs of relapse during chemotherapy.
- Despite treatment with radiotherapy, the patient unfortunately passed away two months later, demonstrating the aggressive nature of this metastasis and the rarity of secondary iris involvement.
Article Abstract
Background: Intraocular iris rhabdomyosarcoma is extremely rare, and in the 3 cases reported to date occurred as the primary site of tumour growth. We report a case of rhabdomyosarcoma of the foot metastasizing to the iris.
Case Presentation: An 18-year-old white female was referred to the London Ocular Oncology Service for management of a metastatic rhabdomyosarcomatous deposit in the iris, a metastasis from alveolar rhabdomyosarcoma of the foot. She was diagnosed nearly 2 years earlier with the primary sarcoma with extensive systemic spread and treated by resection of the foot lesion and chemotherapy, and achieved a partial remission. The left iris deposit was noted while she was receiving systemic chemotherapy, heralding a relapse. However, anterior uveitis and raised intraocular pressure developed and she was referred to our service for further management. A left iris secondary rhabdomyosarcoma deposit was noticed and in addition a lacrimal gland mass, as indicated by ultrasound B scan of the eye and orbit. The patient was treated with external beam radiotherapy to the globe and orbit, but died 2 months after treatment completion.
Conclusion: Rhabdomyosarcoma of the iris is very rare and was previously documented only as a primary malignancy in this location. We report that secondary spread to the iris can also occur, in this case as the first sign of widely disseminated systemic relapse.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4940711 | PMC |
| http://dx.doi.org/10.1186/s12885-016-2496-6 | DOI Listing |
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