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Complications associated with pulsed field ablation vs radiofrequency catheter ablation of atrial fibrillation.
Heart Rhythm
November 2024
Electrophysiology Section, Duke University Medical Center, Duke Clinical Research Institute, Durham, North Carolina; Department of Medicine, Duke University School of Medicine, Durham, North Carolina. Electronic address:
Background: The first commercial systems for pulsed field ablation (PFA) were recently approved by the Food and Drug Administration, but their safety profile in nationwide practice remains underexplored.
Objectives: This study aimed to describe reported adverse events with PFA systems after their market release and to compare the relative proportion of complications associated with PFA vs radiofrequency (RF) ablation catheters.
Methods: We conducted a search of the Manufacturer and User Facility Device Experience database for adverse event reports involving Food and Drug Administration-approved PFA and RF catheters from January 1, 2024, to July 31, 2024.
An international physician survey of current ablation practices in atrial fibrillation: An AIM-AF substudy.
Heart Rhythm
October 2024
Clinical Cardiology Academic Group, Molecular and Clinical Sciences Research Institute, St. George's University of London, London, United Kingdom.
Background: Practice guidelines recommend ablation (ABL) in atrial fibrillation (AF) for rhythm control. Guidance for antiarrhythmic drugs (AADs) post-ABL is limited.
Objective: The purpose of this study was to determine AAD and ABL practices in the United States and Europe.
Discovery and characterization of a pan-betacoronavirus S2-binding antibody.
Structure
November 2024
Vanderbilt Vaccine Center, Vanderbilt University Medical Center, Nashville, TN 37232, USA; Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN 73232, USA; Vanderbilt Institute for Infection, Immunology, and Inflammation, Vanderbilt University Medical Center, Nashville, TN 37232, USA; Department of Computer Science, Vanderbilt University, Nashville, TN 37232, USA; Center for Structural Biology, Vanderbilt University, Nashville, TN 37232, USA; Program in Computational Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN 37232, USA. Electronic address:
Article Synopsis
- - The research focuses on developing pan-coronavirus interventions by identifying 50 antibodies from human B cells, particularly highlighting the antibody 54043-5, which binds to a common part of spike proteins in various coronaviruses.
- - A structural analysis revealed that 54043-5 recognizes a specific, highly conserved region of the S2 subunit in SARS-CoV-2, which is critical for understanding how this antibody can potentially provide protection.
- - Although 54043-5 does not neutralize the virus directly, it activates immune responses that help combat infections, and certain modifications to this antibody showed protective effects in mouse models of SARS-CoV-2 disease.
Discordant Treatment Goals for Patients With Atrial Fibrillation and Clinical Trials Metrics.
JACC Clin Electrophysiol
November 2024
University of Utah Health, Salt Lake City, Utah, USA. Electronic address:
Background: Most clinical trials define successful atrial fibrillation (AF) treatment as no AF episodes longer than 30 seconds. Yet, there has been minimal study of how patients define successful treatment and whether their perspectives align with trial outcomes.
Objectives: Survey patients with AF to identify: 1) what aspect of AF is most important to address (frequency, duration, or severity of AF episodes); 2) what AF burden would be considered acceptable to consider treatment successful; and 3) to establish patient preferences for successful treatment thresholds for a validated patient-reported outcome (PRO) score.
Trajectory correction enables free-running chemical shift encoded imaging for accurate cardiac proton-density fat fraction quantification at 3T.
J Cardiovasc Magn Reson
December 2024
Aix-Marseille Univ, CNRS, CRMBM, Marseille, France; APHM, Hôpital Universitaire Timone, CEMEREM, Marseille, France. Electronic address:
Background: Metabolic diseases can negatively alter epicardial fat accumulation and composition, which can be probed using quantitative cardiac chemical shift encoded (CSE) cardiovascular magnetic resonance (CMR) by mapping proton-density fat fraction (PDFF). To obtain motion-resolved high-resolution PDFF maps, we proposed a free-running cardiac CSE-CMR framework at 3T. To employ faster bipolar readout gradients, a correction for gradient imperfections was added using the gradient impulse response function (GIRF) and evaluated on intermediate images and PDFF quantification.
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