A versatile multistep continuous flow setup is reported for the four-step conversion of anilines into pyrazole products. The synthesis machine incorporates the use of amine-redox chemistry through diazotization and a metal-free vitamin C mediated reduction. The machine can be used for the synthesis of an array of analogues or the scale up of an individual target.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4906367 | PMC |
| http://dx.doi.org/10.1039/c5re00082c | DOI Listing |
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