We report the imaging features of a rare sinonasal myxoma situated over the right nasolacrimal duct in a 5-month-old male. We emphasize the importance of including sinonasal myxomas in the list of differential diagnostic possibilities when encountering a nasolacrimal gland mass in an infant, and describe the CT and MRI characteristics of this rare entity.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4921178PMC
http://dx.doi.org/10.2484/rcr.v10i2.1104DOI Listing

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Our aim is to present two cases of infantile sinonasal tract myxoma with orbital involvement and conduct a comprehensive literature review of the topic. We aim to provide a summary of the presentation of infantile sinonasal tract myxomas to effectively aid clinicians in considering this rare entity as a potential diagnosis. We present a case series and a retrospective review of the published literature in the English language.

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Article Synopsis
  • Sinonasal myxomas (SNMs) are a specific type of tumor found in the paranasal sinuses and maxillae of infants, as seen in a case involving a 15-month-old.
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Spindle Cell Tumors of the Sinonasal Tract: A Diagnostic Update with Focus on Ancillary Workup.

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February 2024

Department of Pathology and Laboratory Medicine, Mount Sinai Hospital and Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada.

Spindle cell neoplasms arising in the head and neck may be challenging to recognize due to their relative rarity. While underlying molecular alterations are increasingly elucidated, testing for these features may not be readily available. In most cases, combinations of key morphologic features and diagnostic immunohistochemical markers can be used to replace molecular diagnostics.

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Sinonasal myxomas are rare benign tumors of the maxillary bone and sinus. There is published evidence that sinonasal myxomas occurring in children up to 3 years of age ("infantile sinonasal myxomas") are clinically distinctive and harbor Wnt signaling pathway alterations. Here, we characterized 16 infantile sinonasal myxomas and compared them to 19 maxillary myxomas and 11 mandibular myxomas in older patients.

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