A complete taxonomic revision of the genus Primnoisis (Isididae) is presented herein, based on original type material of all nominal species and additional specimens from deep-water surveys in sub-temperate and Antarctic waters. A multi-disciplinary approach was used combining morphological characteristics such as colonial branching patterns, polyp structure, sclerite form and arrangement, together with phylogenetic reconstructions using two mitochondrial gene regions (mtMutS and igr1-cox1). The genus Primnoisis is retained with 7 of the 8 nominal species validated (P. antarctica Wright & Studer, 1889, P. rigida Wright & Studer, 1889, P. ambigua Wright & Studer, 1889, P. delicatula Hickson, 1907, P. fragilis Kükenthal, 1912, P. formosa Gravier, 1913 and P. mimas Bayer & Stefani, 1987), with the eighth (P. sparsa Wright & Studer, 1889), synonymised with P. antarctica. In addition, the species Mopsea gracilis Gravier, 1913 is reassigned to Primnoisis and an additional five new species are described (P. chatham n. sp., P. erymna n. sp., P. millerae n. sp., P. niwa n. sp. and P. tasmani n. sp). Most of the species fell into two clear groups, defined both by morphology and genetic grouping, for which two new sub-genera are proposed (P. (Primnoisis) n. subg. and P. (Delicatisis) n. subg.). Three species, P. ambigua, P. mimas and P. tasmani, could not be placed reliably in either sub-genus due to distinctive morphological features or genetic dissimilarity. It was not possible to confirm the monophyly of the genus due to unresolved relationships with the closely related genus Notisis Gravier, 1913 and an undescribed genus of Mopseinae.
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http://dx.doi.org/10.11646/zootaxa.4075.1.1 | DOI Listing |
N Engl J Med
July 2023
From the Departments of Intensive Care (G.E., L.P., R.B.) and Neurology (J.A.), Austin Hospital, the Australian and New Zealand Intensive Care Research Centre (G.E., A.D.N., C.H., S.M., G.C., M.J.B., E.P., B.A., T.T., R.B.), the School of Public Health and Preventive Medicine, Monash University (S.B., D.S.), the Departments of Intensive Care (C.H., S.B., T.T.) and Cardiology (D.S.), Alfred Hospital, the Division of Critical Care (C.H., R.B.) and the Departments of Medicine (J.A.) and Critical Care (A.D.), University of Melbourne, the Department of Intensive Care, Royal Melbourne Hospital (A.D., R.B.), and the Department of Intensive Care, Northern Hospital (A.G.), Melbourne, VIC, the Division of Critical Care, George Institute for Global Health, Sydney (C.H.), and the Intensive Care Unit, Princess Alexandra Hospital, and the School of Medicine, University of Queensland, Brisbane (J.W.) - all in Australia; the Clinical Research Centre at St. Vincent's Hospital, University College Dublin, Dublin (A.D.N., K.A., S.M., C.F.); the Cardiothoracic and Vascular Intensive Care Unit (R.L.P., S.M.) and the Department of Critical Care Medicine (Y.W.C.), Auckland City Hospital, and the School of Nursing, University of Auckland (R.L.P.), Auckland, Intensive Care Research (A.H.), Medical Research Institute of New Zealand (R.L.P., S.M.), and the Intensive Care Unit, Wellington Regional Hospital (E.L.), Wellington, and the Department of Intensive Care, Christchurch Hospital, Canterbury (D.K.) - all in New Zealand; the Sections of Anesthesiology and Intensive Care (N.N., J.D.), Cardiology (J.D.), and Neurology (G. Lilja, T.C.), Department of Clinical Sciences, Lund University, Skåne University Hospital, Lund, Helsingborg Hospital, Helsingborg (N.N.), and the Department of Anesthesia and Intensive Care Medicine, Skåne University Hospital, Malmo (J.P.D.) - all in Sweden; the Departments of Emergency Care and Services (M.B.S.) and Intensive Care (M.B.), Helsinki University Hospital and University of Helsinki, and the Department of Neurology, Helsinki University Hospital (M. Tiainen) - all in Helsinki; the Department of Intensive Care, Hôpital Universitaire de Bruxelles-Université Libre de Bruxelles (F.S.T.), and the Department of Intensive Care, Erasme University Hospital (F.A.) - both in Brussels; the Department of Critical Care Medicine, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Canada (D.K.); the Emergency Department and Department of Clinical Medicine, Aarhus University Hospital and Aarhus University (H.K.), the Departments of Intensive Care Medicine (A.M.G., S.C., H.M.-A.) and Anesthesiology and Intensive Care (A.G.), Aarhus University Hospital, and the Department of Clinical Medicine, Aarhus University (A.M.G.) - all in Aarhus, Denmark; Reanimation Medicale, Centre Hospitalier Universitaire, Franche-Comte, Unité de Formation et de Recherche Santé, University of Franche-Comte, Besançon, France (G.C.); the Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, and the School of Medicine, Vita-Salute San Raffaele University, Milan (G. Landoni); the Department of Intensive Care, Amsterdam University Medical Centers, Amsterdam (J.H.); the Department of Anesthesiology and Intensive Care Medicine, Institute of Clinical Medicine, University of Oslo (T.O.), and the Department of Cardiology, Oslo University Hospital-Ullevål (G.Ø.A., E.Q., A.F.) - both in Oslo; the Intensive Care Department, Ministry of National Guard Health Affairs, the College of Medicine, King Saud bin Abdulaziz University Hospital for Health Sciences, and King Abdullah International Medical Research Center - all in Riyadh, Saudi Arabia (Y.A., H.T.); the Cardiology Department, Tan Tock Seng Hospital, the School of Medicine, National University of Singapore Yong Loo Lin School of Medicine, and the Department of Medicine, Nanyang Technological University Lee Kong Chian School of Medicine - all in Singapore (Y.W.C.); the Department of Internal Intensive Medicine, University Medical Center Maribor, Maribor, Slovenia (A.M., F.S.); the Department of Intensive Care Medicine, Bern University Hospital (M.H.), and the Departments of Intensive Care Medicine (M.I.) and Anesthesiology and Pain Medicine (A.L.), Inselspital, Bern University Hospital, University of Bern, Bern, and the Institute of Intensive Care Medicine, University Hospital of Zurich, Zurich (M.P.H.) - all in Switzerland; and the Department of Adult Critical Care, University Hospital of Wales, Cardiff (M.P.W., J.C.), the Intensive Care Unit, Bristol Royal Infirmary, Bristol (M. Thomas, K.S., J.B.), the Regional Intensive Care Unit, Royal Victoria Hospital (P.J.M.), and the Wellcome-Wolfson Institute for Experimental Medicine, Queen's University Belfast (P.J.M.), Belfast, and the Academic Department of Critical Care, Queen Alexandra Hospital, Portsmouth (D.P.) - all in the United Kingdom.
JAMA
January 2023
Peter Munk Cardiac Centre at University Health Network, Toronto, Ontario, Canada.
Importance: The longer-term effects of therapies for the treatment of critically ill patients with COVID-19 are unknown.
Objective: To determine the effect of multiple interventions for critically ill adults with COVID-19 on longer-term outcomes.
Design, Setting, And Participants: Prespecified secondary analysis of an ongoing adaptive platform trial (REMAP-CAP) testing interventions within multiple therapeutic domains in which 4869 critically ill adult patients with COVID-19 were enrolled between March 9, 2020, and June 22, 2021, from 197 sites in 14 countries.
JAMA
February 2021
Department of Emergency Medicine, Emory University, Atlanta, Georgia.
Importance: Sepsis is a common syndrome with substantial morbidity and mortality. A combination of vitamin C, thiamine, and corticosteroids has been proposed as a potential treatment for patients with sepsis.
Objective: To determine whether a combination of vitamin C, thiamine, and hydrocortisone every 6 hours increases ventilator- and vasopressor-free days compared with placebo in patients with sepsis.
Zookeys
November 2020
Laboratory of Marine Organism Taxonomy and Phylogeny, Institute of Oceanology, Chinese Academy of Sciences, Qingdao 266071, China Institute of Oceanology, Chinese Academy of Sciences Qingdao China.
Explorations of seamounts in the Western Pacific Ocean and South China Sea resulted in collecting 18 specimens of golden gorgonians. Based on the morphology and the genetic analysis of mtMutS, they are described as one new species, , and four known species, including Xu, Zhan & Xu, 2020, (Wright & Studer, 1889), Kükenthal, 1919, and Pante & France, 2010. belongs to the "group A, Spiculosae" with rods or spindles distributed in the polyp-body wall and tentacles, and differs from all of its congeners except by the 1/3L branching sequence and amoeba-shaped sclerites at the basal polyp body.
View Article and Find Full Text PDFN Engl J Med
May 2019
The affiliations of the members of the writing committee are as follows: the Departments of Medicine (M.M.) and Emergency Medicine (A.A.G.), University of Colorado School of Medicine, Aurora; the Departments of Critical Care Medicine (D.T.H., D.C.A.) and Emergency Medicine (D.M.Y.), University of Pittsburgh School of Medicine, Pittsburgh; the Department of Medicine, Johns Hopkins University School of Medicine, Baltimore (R.G.B.); the Interdepartmental Division of Critical Care Medicine, Department of Medicine, University Health Network and Sinai Health System, University of Toronto, Toronto (N.D.F.); the Department of Medicine, Montefiore Hospital, New York (M.N.G.); the Department of Medicine, Intermountain Medical Center and the University of Utah, Salt Lake City (C.K.G.); the Department of Medicine, University of Washington, Seattle (S.G., C.L.H.); the Biostatistics Center (D.H.), the Department of Medicine (B.T.T.), and the PETAL Network Clinical Coordinating Center (C.A.U.), Massachusetts General Hospital, the Department of Emergency Medicine, Division of Emergency Critical Care Medicine, Brigham and Women's Hospital (P.C.H.), and the Department of Anesthesia, Critical Care, and Pain Medicine, Beth Israel Deaconess Medical Center (D.T.) - all in Boston; the Department of Critical Care, Respiratory Institute, Cleveland Clinic, Cleveland (R.D.H.); the Department of Medicine, University of Michigan and Veterans Affairs Center for Clinical Research, Ann Arbor (T.J.I.); the Department of Medicine, Oregon Health and Science University, Portland (A.K.); and the Departments of Medicine and Anesthesia, University of California, San Francisco, San Francisco (K.D.L.).
Background: The benefits of early continuous neuromuscular blockade in patients with acute respiratory distress syndrome (ARDS) who are receiving mechanical ventilation remain unclear.
Methods: We randomly assigned patients with moderate-to-severe ARDS (defined by a ratio of the partial pressure of arterial oxygen to the fraction of inspired oxygen of <150 mm Hg with a positive end-expiratory pressure [PEEP] of ≥8 cm of water) to a 48-hour continuous infusion of cisatracurium with concomitant deep sedation (intervention group) or to a usual-care approach without routine neuromuscular blockade and with lighter sedation targets (control group). The same mechanical-ventilation strategies were used in both groups, including a strategy involving a high PEEP.
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