The number of alien species in the Mediterranean Sea is steadily increasing and it seems that the pace has been accelerating since the turn of the century (Galil et al. 2014). In 2015 alone five additional fish species have been reported, Epinephelus geoffroyi (Klunzinger, 1870) (Golani et al. 2015); Stolephorus indicus (van Hasselt, 1823) (Fricke et al. 2015); Sardinella gibbosa (Bleeker, 1849) (Stern et al. 2015); Mobula japanica (Müller & Henle, 1841) (Capapé et al. 2015); and Cryptocentrus caeruleopunctatus (Rüppell, 1830) (Rothman & Goren 2015). Among the ca. 100 alien fish species reported from the Mediterranean to date (Galil & Goren 2014), five Indo-Pacific species belong to the genus Epinephelus Bloch, 1793: Epinephelus coioides (Hamilton, 1822), Epinephelus fasciatus (Forsskål, 1775), Epinephelus malabaricus (Bloch and Schneider, 1804) Epinephelus merra Bloch, 1793 (Golani et al. 2013a) and Epinephelus geoffroyi (Klunzinger, 1870) (Golani et al. 2015). Additional alien Epinephelus species reported from the Mediterranean are excluded for various reasons (Golani et al. 2013b). Here we report the finding of a sixth Indo-Pacific species of this genus along the Mediterranean coast of Israel.
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http://dx.doi.org/10.11646/zootaxa.4067.4.7 | DOI Listing |
Sci Rep
December 2024
Department of Pharmaceutical Chemistry, Dr. D. Y. Patil Institute of Pharmaceutical Sciences and Research, Pimpri, Pune, India.
The emergence of self-propelling magnetic nanobots represents a significant advancement in the field of drug delivery. These magneto-nanobots offer precise control over drug targeting and possess the capability to navigate deep into tumor tissues, thereby addressing multiple challenges associated with conventional cancer therapies. Here, Fe-GSH-Protein-Dox, a novel self-propelling magnetic nanobot conjugated with a biocompatible protein surface and loaded with doxorubicin for the treatment of triple-negative breast cancer (TNBC), is reported.
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December 2024
Negaunee Integrative Research Center, Field Museum, 1400 S. Dusable Lake Shore Drive, Chicago, IL, 60605, USA.
Enantiornithes are the most successful early-diverging avian clade, their fossils revealing important information regarding the structure of Cretaceous avifaunas and the parallel refinement of flight alongside the ornithuromorph lineage that includes modern birds. The most diverse recognized family of Early Cretaceous enantiornithines is the Bohaiornithidae, known from the Jehol Biota in northeastern China. Members of this clade enhance our understanding of intraclade morphological diversity and elucidate the independent evolution of this unique lineage.
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December 2024
BioSpyder Technologies, Inc., Carlsbad, CA, USA.
We report the development and performance of a novel genomics platform, TempO-LINC, for conducting high-throughput transcriptomic analysis on single cells and nuclei. TempO-LINC works by adding cell-identifying molecular barcodes onto highly selective and high-sensitivity gene expression probes within fixed cells, without having to first generate cDNA. Using an instrument-free combinatorial indexing approach, all probes within the same fixed cell receive an identical barcode, enabling the reconstruction of single-cell gene expression profiles across as few as several hundred cells and up to 100,000 + cells per sample.
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December 2024
Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A*STAR), 61 Biopolis Drive, Proteos, Singapore, 138673, Republic of Singapore.
Signaling interplay between the histamine 1 receptor (H1R) and transient receptor potential cation channel subfamily V member 1 (TRPV1) in mediating histaminergic itch has been well-established in mammalian models, but whether this is conserved in humans remains to be confirmed due to the difficulties in obtaining human sensory neurons (SNs) for experimentation. Additionally, previously reported species-specific differences in TRPV1 function indicate that use of human SNs is vital for drug candidate screening to have a higher chance of identifying clinically effective TRPV1 antagonists. In this study, we built a histamine-dependent itch model using peripheral SNs derived from human induced pluripotent stem cells (hiPSC-SNs), which provides an accessible source of human SNs for pre-clinical drug screening.
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December 2024
Laboratory of Respiratory Diseases and Thoracic Surgery (BREATHE), Department of Chronic Diseases and Metabolism, KU Leuven, Leuven, Belgium.
The lungs of people with cystic fibrosis (PwCF) are characterized by recurrent bacterial infections and inflammation. Infections in cystic fibrosis (CF) are left unresolved despite excessive neutrophil infiltration. The role of CFTR in neutrophils is not fully understood.
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