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Case Report: Disseminated Paracoccidioidomycosis and Strongyloides Hyperinfection in a Patient with Human T-Lymphotropic Virus Type 1/2 Infection.
Am J Trop Med Hyg
May 2024
Instituto de Investigaciones en Ciencias Biomédicas, Universidad Ricardo Palma, Lima, Perú.
Co-occurrence of paracoccidioidomycosis and strongyloidiasis in immunosuppressed patients, particularly those infected with human T-lymphotropic virus type 1/2, is infrequent. We describe the case of a Peruvian farmer from the central jungle with human T-lymphotropic virus type 1/2 infection, with 2 months of illness characterized by respiratory and gastrointestinal symptoms associated with fever, weight loss, and enlarged lymph nodes. Strongyloides stercoralis and Paracoccidioides brasiliensis were isolated in sputum and bronchoalveolar lavage samples, respectively.
View Article and Find Full Text PDFMycophenolate mofetil for the long-term treatment of HTLV-1 associated myelopathy: A case report.
J Neuroimmunol
March 2024
The George Washington University School of Medicine and Health Sciences, Ross Hall, 2300 I Street NW, Washington, DC 20052, USA.
Human T-cell leukemia virus type 1 (HTLV-1) can cause HTLV-1 Associated Myelopathy/Tropical Spastic Paraparesis (HAM/TSP). Current treatment options for HAM/TSP are limited. We present a woman with rapidly-progressive HAM/TSP with significant, sustained clinical improvement following initiation of mycophenolate mofetil (MMA).
View Article and Find Full Text PDFMetagenomic analysis fecal microbiota of dysentery-like diarrhoea in a pig farm using next-generation sequencing.
Front Vet Sci
October 2023
Institute of Biotechnology, Fujian Academy of Agricultural Sciences, Fuzhou, Fujian, China.
Porcine enteric diseases including swine dysentery involves a wide range of possible aetiologies and seriously damages the intestine of pigs of all ages. Metagenomic next-generation sequencing is commonly used in research for detecting and analyzing pathogens. In this study, the feces of pigs from a commercial swine farm with dysentery-like diarrhea was collected and used for microbiota analysis by next-generation sequencing.
View Article and Find Full Text PDFRigosertib is more potent than wortmannin and rapamycin against adult T-cell leukemia-lymphoma.
Biofactors
December 2023
Bioinformatics Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
Human T lymphotropic virus type 1 (HTLV-1) infection can cause adult T-cell lymphoblastic leukemia (ATLL), an incurable, chemotherapy-resistant malignancy. In a quest for new therapeutic targets, our study sought to determine the levels of AKT, mTOR, and PI3K in ATLL MT-2 cells, HTLV-1 infected NIH/3T3 cells (Inf-3T3), and HTLV-1 infected patients (Carrier, HAM/TSP, and ATLL). Furthermore, the effects of rigosertib, wortmannin, and rapamycin on the PI3K/Akt/mTOR pathway to inhibit the proliferation of ATLL cells were examined.
View Article and Find Full Text PDFHTLV-I associated bronchioloalveolar disorder (HABA): disease concept and differential diagnosis of an unsolved disease entity.
Expert Rev Anti Infect Ther
January 2023
Department of General Internal Medicine, Pref Osaka Saiseikai Izuo Hospital, Osaka, Japan.
Introduction: Human T-cell leukemia virus type 1 (HTLV-I) associated bronchioloalveolar disorder (HABA) is a chronic and progressive bronchiolar/alveolar disorder related to HTLV-1 infection. Clinical knowledge and guidance are lacking for the diagnosis and management of this condition.
Areas Covered: This work aimed to review the latest information and challenges regarding HABA diagnosis and treatment.
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