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Fecal propionate is a signature of insulin resistance in polycystic ovary syndrome.
Front Cell Infect Microbiol
January 2025
Center of Reproductive Medicine, Shengjing Hospital of China Medical University, Shenyang, China.
Objective: To investigate the roles of fecal short-chain fatty acids (SCFAs) in polycystic ovary syndrome (PCOS).
Methods: The levels of SCFAs (acetate, propionate, and butyrate) in 83 patients with PCOS and 63 controls were measured, and their relationships with various metabolic parameters were analyzed. Intestinal microbiome analysis was conducted to identify relevant bacteria.
Lycopene Ameliorates Polycystic Ovary Syndrome in Rats by Inhibiting Ovarian Ferroptosis Through Activation of the AMPK/Nrf2 Pathway.
J Biochem Mol Toxicol
February 2025
Department of Gynecology, People's Hospital of Xinjiang Uygur Autonomous Region, Urumqi, China.
Lycopene (LYC) is an extremely powerful antioxidant with the potential to treat a range of diseases and to inhibit ferroptosis. This research aims to elucidate how LYC impacts polycystic ovarian syndrome (PCOS) and the action mechanisms. A PCOS rat model was constructed by injecting DHEA.
View Article and Find Full Text PDFFormononetin ameliorates polycystic ovary syndrome through suppressing NLRP3 inflammasome.
Mol Med
January 2025
Reproduction and Genetics Center, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, 42 Wenhua West Road, Lixia District, Jinan, 250014, Shandong, China.
Background: Polycystic ovary syndrome (PCOS) is a common gynecological disease accompanied by multiple clinical features, including anovulation, hyperandrogenism, and polycystic ovarian morphology, leading to infertility. Formononetin (FMN), which is a major bioactive isoflavone compound in Astragalus membranaceus, exerts anti-inflammatory effects. However, whether FMN is effective in the treatment of PCOS remains unknown.
View Article and Find Full Text PDFLow progesterone levels and their role in the co-existence of polycystic ovary syndrome and rheumatoid arthritis: a comprehensive analysis among Iraqi patient.
J Steroid Biochem Mol Biol
January 2025
Department of chemistry-College of Science- Mustansiriyah University, Baghdad. Electronic address:
Polycystic ovarian syndrome (PCOS) is a low-grade and chronic inflammation defined by irregular hormonal status that primarily triggers females in their reproductive age. Multi cysts are a primary manifestation of PCOS; a high level of androgen production characterizes the condition via ovaries. Rheumatoid arthritis (RA) is a chronic, systemic, and symmetrical inflammatory autoimmune disease that affects 1-2% of adults.
View Article and Find Full Text PDFEffects of vaginal microbiota on fertilization outcomes in women with different infertility causes.
Microbiol Spectr
January 2025
School of Public Health, the Key Laboratory of Environmental Pollution Monitoring and Disease Control, Ministry of Education, Guizhou Medical University, Guiyang, Guizhou, China.
Unlabelled: Backed by advancements in technologies like microbial sequencing, many studies indicate that the vaginal microbiome is a key marker of female reproductive health. However, further studies are still needed to investigate the correlation between vaginal microbiota (VMB) and outcomes of assisted reproductive technology (ART). Therefore, this study compared the VMB of two types of infertile women undergoing fertilization (IVF) with normal control women during the implantation window period and investigated the effects of VMB characteristics on IVF outcomes.
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