We present the design procedure for switchable acoustic demultiplexers based on a fluid-fluid phononic crystal (PnC) platform. It consists of a T-shaped PnC waveguide coupled to two output waveguide ports through two dissimilar point-defect cavities. The PnC platform consists of a periodic array of infinitely long rods of water (inclusions) embedded in mercury background. The waveguides are made by the removal of a row or a column of inclusions from the PnC, while the fluid in one of the two dissimilar cavities is methyl nonafluorobutyl ether (MNE) and in the other is ethyl nonafluorobutyl ether (ENE). The difference in the sound velocity in MNE and ENE provides an adequate difference in the dissimilar cavities resonant modes, required for the demultiplexing functionality of the designed structure. The different dependences of the sound velocities in these two fluids on temperature have also enabled the switching of the multiplexed channel, simply by appropriately changing the cavities temperature.
Download full-text PDF |
Source |
---|---|
http://dx.doi.org/10.1109/TUFFC.2016.2586489 | DOI Listing |
J R Soc Interface
January 2025
SSM- School for Advanced Studies Via Mezzocannone 4, Naples 80138, Italy.
This article presents the first implementation of a proportional-integral-derivative (PID) biomolecular controller within a consortium of different cell populations, aimed at robust regulation of biological processes. By leveraging the modularity and cooperative dynamics of multiple engineered cell populations, we develop a comprehensive analysis of the performance and robustness of P, PD, PI and PID control architectures. Our theoretical findings, validated through experiments using the BSim agent-based simulation platform for bacterial populations, demonstrate the robustness and effectiveness of our multicellular PID control strategy.
View Article and Find Full Text PDFSmall Methods
January 2025
NEST, Istituto Nanoscienze - CNR and Scuola Normale Superiore, Pisa, I-56127, Italy.
A ground-breaking graphene-based biosensor designed for label-free detection of immunoglobulin M (IgM) achieving a remarkable concentration of 100 zeptomolar (10 m), is reported. The sensor is a two-terminal device and incorporates a millimeter-wide gold interface, bio-functionalized with ≈10 anti-IgM antibodies and capacitively coupled to a bare graphene electrode through a water-soaked paper strip. In this configuration, few affinity binding events trigger a collective electrostatic reorganization of the protein layer, leading to an extended surface potential (SP) shift of the biofunctionalized Au surface.
View Article and Find Full Text PDFInt J Mol Sci
December 2024
Department of Experimental Medicine, University of Rome "Tor Vergata", Via Montpellier 1, 00133 Rome, Italy.
Breast cancer is the most common cancer and the second leading cause of cancer-related death in women. In advanced stages of the disease, breast cancer can spread and metastasize to the bone, contributing to malignant progression. The roles of tissue stiffness and remodeling of the tumor microenvironment are relevant in influencing cancer progression and invasiveness, but they are still poorly understood.
View Article and Find Full Text PDFClin Chem Lab Med
November 2024
Department of Medicine - DIMED, University of Padova, Padova, Italy.
Int J Mol Sci
October 2024
National Research Council of Italy, Institute for Biomedical Research and Innovation (CNR-IRIB), Via Ugo La Malfa, 153, 90146 Palermo, PA, Italy.
To date, the public health system has been impacted by the increasing costs of many diagnostic and therapeutic pathways due to limited resources. At the same time, we are constantly seeking to improve these paths through approaches aimed at personalized medicine. To achieve the required levels of diagnostic and therapeutic precision, it is necessary to integrate data from different sources and simulation platforms.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!