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| http://dx.doi.org/10.1371/journal.ppat.1005633 | DOI Listing |
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Roles of alcohol dehydrogenase 1 in the biological activities of .
Crit Rev Microbiol
June 2024
School of Life Science and Technology, China Pharmaceutical University, Nanjing, China.
stands as the foremost prevalent human commensal pathogen and a significant contributor to nosocomial fungal infections. In the metabolism of , alcohol dehydrogenase 1 (Adh1) is one of the important enzymes that converts acetaldehyde produced by pyruvate decarboxylation into ethanol at the end of glycolysis. Leveraging the foundational processes of alcoholic fermentation, Adh1 plays an active role in multiple biological phenomena, including biofilm formation, interactions between different species, the development of drug resistance, and the potential initiation of gastrointestinal cancer.
View Article and Find Full Text PDFExploring host-commensal-pathogen dynamics in cell line and organotypic human intestinal epithelial models.
iScience
May 2024
Center for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven, the Netherlands.
Host and microbiome intricately interact in the ecosystem of the human digestive tract, playing a crucial role in our health. These interactions can initiate immune responses in the epithelial cells, which, in turn, activate downstream responses in other immune cells. Here, we used a CaCo-2 and a human intestinal enteroid (HIE) model to explore epithelial responses to both commensal and pathogenic bacteria, individually and combined.
View Article and Find Full Text PDFIntegrating research on bacterial pathogens and commensals to fight infections-an ecological perspective.
Lancet Microbe
August 2024
Interfaculty Institute of Microbiology and Infection Medicine Tübingen, University of Tübingen, Tübingen, Germany; Cluster of Excellence "Controlling Microbes to Fight Infections" (CMFI), Tübingen, Germany; German Center for Infection Research, partner site, Tübingen, Germany. Electronic address:
The incidence of antibiotic-resistant bacterial infections is increasing, and development of new antibiotics has been deprioritised by the pharmaceutical industry. Interdisciplinary research approaches, based on the ecological principles of bacterial fitness, competition, and transmission, could open new avenues to combat antibiotic-resistant infections. Many facultative bacterial pathogens use human mucosal surfaces as their major reservoirs and induce infectious diseases to aid their lateral transmission to new host organisms under some pathological states of the microbiome and host.
View Article and Find Full Text PDFAirway commensal bacteria in cystic fibrosis inhibit the growth of P. aeruginosa via a released metabolite.
Microbiol Res
June 2024
Institute of Medical Microbiology and Virology, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany. Electronic address:
In cystic fibrosis (CF), Pseudomonas aeruginosa infection plays a critical role in disease progression. Although multiple studies suggest that airway commensals might be able to interfere with pathogenic bacteria, the role of the distinct commensals in the polymicrobial lung infections is largely unknown. In this study, we aimed to identify airway commensal bacteria that may inhibit the growth of P.
View Article and Find Full Text PDFHuman PRH1, PRH2 susceptibility and resistance and Streptococcus mutans virulence phenotypes specify different microbial profiles in caries.
EBioMedicine
March 2024
Department of Odontology/Cariology, Umeå University, 901 87, Umeå, Sweden. Electronic address:
Background: Lifestyle- and sucrose-dependent polymicrobial ecological shifts are a primary cause of caries in populations with high caries prevalence. In populations with low prevalence, PRH1, PRH2 susceptibility and resistance phenotypes may interact with the Streptococcus mutans adhesin cariogenicity phenotype to affect caries progression, but studies are lacking on how these factors affect the microbial profile of caries.
Methods: We analysed how the residency and infection profiles of S.
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