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http://dx.doi.org/10.1136/jmg.26.6.410 | DOI Listing |
BMC Bioinformatics
January 2025
Auburn University, Auburn, AL, 36849, USA.
Background: Pacific Biosciences (PacBio) circular consensus sequencing (CCS), also known as high fidelity (HiFi) technology, has revolutionized modern genomics by producing long (10 + kb) and highly accurate reads. This is achieved by sequencing circularized DNA molecules multiple times and combining them into a consensus sequence. Currently, the accuracy and quality value estimation provided by HiFi technology are more than sufficient for applications such as genome assembly and germline variant calling.
View Article and Find Full Text PDFChem Asian J
January 2025
University of Kalyani, Chemistry, Kalyani, 741235, Kalyani, INDIA.
Herein, we report the synthesis of copillar[5]arene-based pyrene Schiff base 1 and its characterization by using 1H, 13C NMR, FT-IR and mass spectrometry. UV-vis absorption, steady-state fluorescence and time-resolved fluorescence are done to elucidate the photophysical behaviors of 1. To understand the electronic structure of 1, density functional theory (DFT) calculations are performed.
View Article and Find Full Text PDFACS Nano
January 2025
Bragg Centre for Materials Research, School of Electronic and Electrical Engineering, University of Leeds, Leeds LS2 9JT, U.K.
The field of nanopore sensing is now moving beyond nucleic acid sequencing. An exciting avenue is the use of nanopore platforms for the monitoring of biochemical reactions. Biological nanopores have been used for this application, but solid-state nanopore approaches have lagged.
View Article and Find Full Text PDFComput Methods Programs Biomed
January 2025
Guizhou Province International Science and Technology Cooperation Base for Precision Imaging Diagnosis and Treatment, Key Laboratory of Advanced Medical Imaging and Intelligent Computing of Guizhou Province, Department of Radiology, Guizhou Provincial People's Hospital, Guizhou 550002, China. Electronic address:
Background And Objective: Accurate segmentation of the prostate region in magnetic resonance imaging (MRI) is crucial for prostate-related diagnoses. Recent studies have incorporated Transformers into prostate region segmentation to better capture long-range global feature representations. However, due to the computational complexity of Transformers, these studies have been limited to processing single slices.
View Article and Find Full Text PDFPhys Med Biol
January 2025
School of Software Engineering, Xi'an Jiaotong University, Xi 'an Jiaotong University Innovation Port, Xi 'an, Shaanxi Province, Xi'an, Shaanxi, 710049, CHINA.
Deformable registration aims to achieve nonlinear alignment of image space by estimating a dense displacement field. It is commonly used as a preprocessing step in clinical and image analysis applications, such as surgical planning, diagnostic assistance, and surgical navigation. We aim to overcome these challenges: Deep learning-based registration methods often struggle with complex displacements and lack effective interaction between global and local feature information.
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