Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.ijantimicag.2016.06.001 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Glabridin restore the sensitivity of colistin against mcr-1-positive Escherichia coli by polypharmacology mechanism.
Microbiol Res
January 2025
College of Veterinary Medicine, Northeast Agricultural University, Harbin, China. Electronic address:
The clinical effectiveness of colistin against multidrug-resistant Gram-negative pathogen infections has been threatened by the emergence of the plasmid-mediated colistin-resistant gene mcr-1. This development underscores the urgent need for innovative therapeutic strategies that target resistance mechanisms. In this study, we demonstrated that glabridin can restore the sensitivity of colistin to mcr-1-positive Escherichia coli (E.
View Article and Find Full Text PDFDissemination of clinical harboring the gene in Pakistan.
Front Microbiol
January 2025
Institute of Microbiology, University of Agriculture, Faisalabad, Pakistan.
Background: Colistin is an antibiotic used as a last resort to treat multidrug-resistant Gram-negative bacterial infections. Plasmid-mediated mobile colistin-resistant () genes in () are disseminated globally and are considered to be a major public health threat. This study aimed to determine the molecular characteristics of colistin-resistant isolates in clinical settings in Pakistan.
View Article and Find Full Text PDFStudy on the Mobile Colistin Resistance (mcr-1) Gene in Gram-Negative Bacilli in a Rural Tertiary Care Hospital in Western Maharashtra.
Cureus
December 2024
Department of Microbiology, Krishna Institute of Medical Sciences, Krishna Vishwa Vidyapeeth, Karad, IND.
Background: Colistin, a last-resort antibiotic for treating multidrug-resistant Gram-negative bacterial infections, has increased resistance as a result of the emergence of the gene. The 1gene, which confers colistin resistance, is often carried on plasmids, facilitating its spread by horizontal gene transfer among bacterial populations. The rising prevalence of 1mediated resistance poses significant challenges for infection control and treatment efficacy.
View Article and Find Full Text PDFThe First Report of -1-Carrying , Isolated from a Clinical Sample in the North-East of Romania.
Microorganisms
November 2024
Department of Microbiology, Faculty of Medicine, "Grigore T. Popa" University of Medicine and Pharmacy, 16 Universitatii Street, 700115 Iași, Romania.
Colistin resistance poses a significant clinical challenge, particularly in Gram-negative bacteria. This study investigates the occurrence of plasmid-mediated colistin resistance among isolates (, , and spp.) and non-fermentative rods ( and ).
View Article and Find Full Text PDFCarriage of antimicrobial resistance genes in Escherichia coli of bovine origin.
Pol J Vet Sci
December 2024
Department of Animal Nutrition and Husbandry, University of Veterinary Medicine and Pharmacy in Košice, Komenského 73, Košice, 04181, Slovakia.
The present study aimed to search for the presence of the plasmid-mediated antimicrobial resistance genes in 106 Escherichia coli (E. coli) isolates from a total of 240 fresh fecal samples collected from 12 private cattle farms in Bingol province of East Turkey from November 2021 to January 2022. In those colistin-resistant E.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!