Introduction: Several compositions of neutron filters have been installed at the channel No. 4 of the Dalat research reactor to produce quasi-monoenergetic neutron beams. However, this neutron facility has been proposed to enhance the quality of the experimental instruments, and to characterize the neutron spectrum parameters for new filtered neutron beams of 2 keV, 24 keV, 59 keV and 133 keV.
Case Description: In order to meet the demand of neutron spectrum information for calculation and design of filtered neutron facilities at the Dalat nuclear research reactor (DNRR), the experimental determinations of neutron flux and energy spectrum, up to 8 MeV, has been performed at the inner entrance of the horizontal channel No. 4 from the core of DNRR. The Westcott neutron fluxes as well as the α-parameter that represents the deviation of epithermal neutron distribution from the 1/E law were measured by applying the cadmium ratio and the multi-foils activation methods. The fast neutron spectrum was measured based on the iterative adjustment procedure with threshold reactions.
Discussion And Evaluation: A set of pure metal thin foils with the diameter of 1.27 cm and thickness of 0.125 mm were used as threshold detectors to measure the integrated fluxes, and a calculation procedure on iterative adjustment was implemented to derive the differential neutron energy spectrum from the integrated values.
Conclusions: The neutron fluxes and spectrum parameters were characterized with the measured values of 4.80 × 10(9), 1.98 × 10(7), 5.06 × 10(8) cm(-2) s(-1) and 0.0448 for the thermal, epithermal, fast neutron fluxes and the α-shape factor, respectively. The present result has been significantly applied to the input data for the Monte Carlo simulations in the developments of filtered mono-energetic neutron beam facility at the institute.
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http://dx.doi.org/10.1186/s40064-016-2585-7 | DOI Listing |
Drug Dev Ind Pharm
January 2025
Institute of Pharmaceutics, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China.
Objective: Boron Neutron Capture Therapy (BNCT) is a novel precision radiotherapy. The key to BNCT application lies in the effective targeting and retention of the boron-10 (B) carrier. Among the various compounds studied in clinical settings, 4-boronophenylalanine (BPA) become the most prevalent one currently.
View Article and Find Full Text PDFSensors (Basel)
December 2024
China Institute of Atomic Energy, P.O. Box 275 (26), Beijing 102413, China.
Fast-neutron reactors are an important representative of Generation IV nuclear reactors, and due to the unique structure and material properties of fast reactor fuel, traditional mechanical cutting methods are not applicable. In contrast, laser cutting has emerged as an ideal alternative. However, ensuring the stability of optical fibers and laser cutting heads under high radiation doses, as well as maintaining cutting quality after irradiation, remains a significant technical challenge.
View Article and Find Full Text PDFCancers (Basel)
January 2025
Istituto Nazionale di Fisica Nucleare, Sezione di Bari, 70125 Bari, Italy.
Background: Boron neutron capture therapy (BNCT) is an innovative binary form of radiation therapy with high selectivity towards cancer tissue based on the neutron capture reaction B(n,α)Li, consisting in the exposition of patients to neutron beams after administration of a boron compound with preferential accumulation in cancer cells. The high linear energy transfer products of the ensuing reaction deposit their energy at the cell level, sparing normal tissue. Although progress in accelerator-based BNCT has led to renewed interest in this cancer treatment modality, in vivo dose monitoring during treatment still remains not feasible and several approaches are under investigation.
View Article and Find Full Text PDFInt J Mol Sci
December 2024
Kurnakov Institute of General and Inorganic Chemistry, Russian Academy of Sciences, Leninskii Pr. 31, 119991 Moscow, Russia.
In this work, a series of boronated amidines based on the -dodecaborate anion and amino acids containing an amino group in the side chain of the general formula [BHNHC(NH(CH)CH(NH)COOH)CH], where n = 2, 3, 4, were synthesized. These derivatives contain conserved α-amino and α-carboxyl groups recognized by the binding centers of the large neutral amino acid transporter (LAT) system, which serves as a target for the clinically applied BNCT agent para-boronophenylalanine (BPA). The paper describes several approaches to synthesizing the target compounds, their acute toxicity studies, and tumor uptake studies in vivo in two tumor models.
View Article and Find Full Text PDFAppl Radiat Isot
January 2025
Kyoto University Graduate School of Engineering, Kyoto Daigaku-katsura, Nishikyo-ku, Kyoto, 615-8530, Japan.
We aimed to explore the possibility of realizing a beam shaping assembly (BSA) driven by a 15-kW beam of 33-MeV electrons of an electron linear accelerator (LINAC) when a boronophenylalanine is adopted as a boron carrier. Simulation calculations were performed to design two types of BSAs driven by the small LINAC. The one was an experimental BSA, and the other was a high-performance BSA.
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