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Clinical Manifestations.
Alzheimers Dement
December 2024
WCG Clinical Endpoint Solutions, Princeton, NJ, USA.
Background: Clinical trials in Alzheimer's Disease (AD) suffer from high failure rates, in part due to imprecision in endpoint measurements that introduces noise. SIA is a quantitative approach that utilizes algorithms to identify inconsistencies in measurements that may be indicative of problematic scale administration and/or scoring errors. The CDR, a sole primary and key secondary endpoint in many AD trials, can be challenging to score, particularly in early symptomatic and mild diseases.
View Article and Find Full Text PDFLeft Ventrolateral Prefrontal Cortical Activity During Reward Expectancy and Mania Risk.
JAMA Psychiatry
January 2025
Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania.
Importance: Mania/hypomania is the pathognomonic feature of bipolar disorder (BD). As BD is often misdiagnosed as major depressive disorder (MDD), replicable neural markers of mania/hypomania risk are needed for earlier BD diagnosis and pathophysiological treatment development.
Objective: To replicate the previously reported positive association between left ventrolateral prefrontal cortex (vlPFC) activity during reward expectancy (RE) and mania/hypomania risk, to explore the effect of MDD history on this association, and to compare RE-related left vlPFC activity in individuals with and at risk of BD.
Blended police firearms training improves performance in shoot/don't shoot scenarios: a systematic replication with police cadets.
Front Psychol
December 2024
Department of Business Studies, Westfälische Hochschule, Gelsenkirchen, Germany.
Senior police officers' tactical gaze control and visual attention improve with an individual video-based police firearms training. To validate the efficacy of said intervention training, a previous experiment was systematically replicated with a sample of = 52 second-year police cadets. Participants were randomly assigned to the intervention training that focused on situational awareness, tactical gaze control, and visual attention, or an active control training that addressed traditional marksmanship skills.
View Article and Find Full Text PDFHeart Failure Masked as Pulmonary Embolism in Non-adherent Patient With Atrial Fibrillation: Case Report and Analytical Review of the Literature.
In Vivo
December 2024
Department of Health and Care Professions, Faculty of Health and Life Sciences, University of Exeter, Exeter, U.K.;
Background/aim: Atrial fibrillation (AF) and heart failure (HF) commonly co-occur, significantly increasing morbidity and mortality. Poorly controlled AF can contribute to complications like HF and is associated with conditions, such as stroke and pulmonary embolism (PE). This report involves a man with AF who had persistent respiratory symptoms and left-sided chest pain, initially suspected to be PE, but eventually diagnosed as HF.
View Article and Find Full Text PDFIsolated Prostate Tuberculosis Mimicking Prostate Cancer.
Ethiop J Health Sci
October 2024
Department of Pathology, Addis Ababa University, College of Health Sciences, Addis Ababa, Ethiopia.
Background: Tuberculosis (TB) remains the deadliest infectious disease globally, with the kidneys being the most frequently affected organ in the genitourinary system. Isolated prostate involvement by tuberculosis is rare and may mimic prostate cancer. This case report aims to highlight the diagnostic challenges and therapeutic responses associated with isolated prostate tuberculosis, particularly in the context of significantly elevated prostate-specific antigen (PSA) levels in a TB-endemic region.
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