AI Article Synopsis
- Vector-borne diseases (VBDs) pose significant risks to human and animal health and impact livestock production, prompting a shift towards developing vaccines for sustainable control.
- Recent advancements in genomics and related technologies have led to innovative "third generation" vaccines that utilize methods like reverse vaccinology and systems biology, which speed up vaccine development and improve candidate discovery.
- The review focuses on these new generation vaccines for VBDs, particularly anti-tick vaccines aimed at reducing both vector populations and the pathogens they carry, while addressing the challenges faced during the vaccine development process.
Article Abstract
Vector-borne diseases (VBDs) present a major threat to human and animal health, as well as place a substantial burden on livestock production. As a way of sustainable VBD control, focus is set on vaccine development. Advances in genomics and other "omics" over the past two decades have given rise to a "third generation" of vaccines based on technologies such as reverse vaccinology, functional genomics, immunomics, structural vaccinology and the systems biology approach. The application of omics approaches is shortening the time required to develop the vaccines and increasing the probability of discovery of potential vaccine candidates. Herein, we review the development of new generation vaccines for VBDs, and discuss technological advancement and overall challenges in the vaccine development pipeline. Special emphasis is placed on the development of anti-tick vaccines that can quell both vectors and pathogens.
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| http://dx.doi.org/10.1039/c6mb00268d | DOI Listing |
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