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Predictive brain activity related to auditory information is associated with performance in speech comprehension tasks in noisy environments.
Front Hum Neurosci
October 2024
Department of Rehabilitation, Faculty of Health Science, Fukui Health Science University, Fukui, Japan.
Introduction: Understanding speech in noisy environments is challenging even for individuals with normal hearing, and it poses a significant challenge for those with hearing impairments or listening difficulties. There are limitations associated with the current methods of evaluating speech comprehension in such environments, especially in individuals with peripheral hearing impairments. According to the predictive coding model, speech comprehension is an active inference process that integrates sensory information through the interaction of bottom-up and top-down processing.
View Article and Find Full Text PDFAn optimal promoter regulating cytokine transgene expression is crucial for safe and effective oncolytic virus immunotherapy.
Transl Res
November 2024
Department of Gene Therapy and Regenerative Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, 8-35-1 Sakuragaoka, Kagoshima 890-8544, Japan; Center for Innovative Therapy Research and Application, Kagoshima University Graduate School of Medical and Dental Sciences, 8-35-1 Sakuragaoka, Kagoshima 890-8544, Japan; South Kyushu Center for Innovative Medical Research and Application, Kagoshima University Graduate School of Medical and Dental Sciences, 8-35-1 Sakuragaoka, Kagoshima 890-8544, Japan; Center for Clinical and Translational Research, Kagoshima University Hospital, 8-35-1 Sakuragaoka, Kagoshima 890-8544, Japan. Electronic address:
In general, ensuring safety is the top priority of a new modality. Although oncolytic virus armed with an immune stimulatory transgene (OVI) showed some promise, the strategic concept of simultaneously achieving maximum effectiveness and minimizing side effects has not been fully explored. We generated a variety of survivin-responsive "conditionally replicating adenoviruses that can target and treat cancer cells with multiple factors (m-CRAs)" (Surv.
View Article and Find Full Text PDFRadiation dose to breast during digital mammography in Tanzania.
Radiat Prot Dosimetry
March 2024
Tanzania Atomic Energy Commission, Block J, Njiro, 23114 Arusha, Tanzania.
The aim of this study was to evaluate the mean glandular dose (MGD), to assess the potential for optimization, and to propose diagnostic reference levels (DRLs). MGD was estimated from air kerma measurements and patient information collected during mammography examinations. The 75th percentile values were determined as the third quartile of the median MGD values for all hospitals, and DRLs set as 75th percentile of MGD values.
View Article and Find Full Text PDFElectrocorticography reveals the dynamics of famous voice responses in human fusiform gyrus.
J Neurophysiol
February 2023
Department of Neurological Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania.
Voice and face processing occur through convergent neural systems that facilitate speaker recognition. Neuroimaging studies suggest that familiar voice processing engages early visual cortex, including the bilateral fusiform gyrus (FG) on the basal temporal lobe. However, what role the FG plays in voice processing and whether it is driven by bottom-up or top-down mechanisms is unresolved.
View Article and Find Full Text PDFObjectives: This study explores how public key players play an important role in social networks for coronavirus (COVID-19).
Methods: This study employs social network analyses based on 2,864 Twitter users and 2,775 communications of Twitter.
Results: This study finds that President Trump plays the most important role in social networks among the top 20 key players for both in-degree centrality and content in tweets.
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