Effects of a synthetic biguanide derivative N-[imino(1-piperidinyl)methyl] guanidine (NIPMG) on free radical homeostasis, aconitase activity, and citrate concentration were studied in the liver and blood serum of rats with type 2 diabetes mellitus. Analysis of biochemiluminescence parameters showed that administration of this agent (10 mg/kg body weight) to animals with diabetes reduced the intensity of free radical processes in study tissues relative to the increased values in untreated diabetic animals. Under these conditions, aconitase activity, a principal target of ROS effects, and citrate level in the liver and blood serum of rats approached the control levels. The results show that NIPMG can positively regulate free radical homeostasis and reduce the intensity of oxidative stress in type 2 diabetes mellitus, which was accompanied by normalization of the studied parameters.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1007/s10517-016-3391-5 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Reconstruction of a 10-cm Defect in the Distal Humerus Using a Lambda-Shaped Free Vascularized Fibular Flap: A Case Report.
JBJS Case Connect
January 2025
Department of Orthopaedics and Trauma, Ganga Medical Centre and Hospitals Pvt, Coimbatore, Tamil Nadu, India.
Case: A 48-year-old man with multiple injuries sustained a Gustilo type 3A right open distal humerus fracture with a 4-cm wound, contralateral radius shaft, and ilium fractures. Following wound irrigation on the day of injury, second look debridement showed crushed triceps and severe contamination extending into the distal humerus medullary canal. After 6 days of initial plate fixation, he developed signs of deep infection.
View Article and Find Full Text PDFThe impact of intermittent preventive treatment in school aged children with dihydroartemisinin piperaquine and artesunate amodiaquine on IgG response against six blood stage Plasmodium falciparum antigens.
PLoS One
January 2025
Tanga Research Centre, National Institute for Medical Research, Tanga, Tanzania.
Several interventional strategies have been implemented in malaria endemic areas where the burden is high, that include among others, intermittent preventive treatment (IPT), a tactic that blocks transmission and can reduce disease morbidity. However, the implementation IPT strategies raises a genuine concern, intervening the development of naturally acquired immunity to malaria which requires continuous contact with parasite antigens. This study investigated whether dihydroartemisinin-piperaquine (DP) or artesunate-amodiaquine (ASAQ) IPT in schoolchildren (IPTsc) impairs IgG reactivity to six malaria antigens.
View Article and Find Full Text PDFA new computational framework for simulating airway resistance, fraction of exhaled nitric oxide, and diffusing capacity for nitric oxide.
PLoS One
January 2025
Transfers, Interfaces and Processes, Université libre de Bruxelles, Brussels, Belgium.
In this paper, we present a new computational framework for the simulation of airway resistance, the fraction of exhaled nitric oxide, and the diffusion capacity for nitric oxide in healthy and unhealthy lungs. Our approach is firstly based on a realistic representation of the geometry of healthy lungs as a function of body mass, which compares well with data from the literature, particularly in terms of lung volume and alveolar surface area. The original way in which this geometry is created, including an individual definition of the airways in the first seven generations of the lungs, makes it possible to consider the heterogeneous nature of the lungs in terms of perfusion and ventilation.
View Article and Find Full Text PDFOxygen Activation Biocatalytic Precipitation Strategy Based on a Bimetallic Single-Atom Catalyst for Photoelectrochemical Biosensing.
Anal Chem
January 2025
Key Laboratory of Optic-Electric Sensing and Analytical Chemistry for Life Science, MOE; College of Chemistry and Molecular Engineering, Qingdao University of Science and Technology, Qingdao 266042, PR China.
Article Synopsis
- The traditional biocatalytic precipitation (BCP) method has limitations due to HO's tendency to self-decompose, affecting its effectiveness in quantitative analysis.
- Researchers discovered that a bimetallic single-atom catalyst (Co/Zn-N-C SAC) can activate dissolved oxygen to create reactive oxygen species, leading to improved detection methods.
- The development of a new oxygen-activated photoelectrochemical (PEC) biosensor for chloramphenicol (CAP) detection demonstrates enhanced stability and accuracy by using Co/Zn-N-C SAC and cesium platinum bromide nanocrystals (CsPtBr NCs) without needing external reactants.
Disentangling Driving Force Effects, Polar Effects, /H Imbalance, and Other Influences on H-Atom Transfer Reactions.
J Am Chem Soc
January 2025
Department of Chemistry, Yale University, 225 Prospect Street, New Haven, Connecticut 06520, United States.
Hydrogen atom transfer (HAT) reactions and their kinetic barriers Δ are important in organic and inorganic chemistry. This study examines factors that influence Δ, reporting the kinetics and thermodynamics of HAT from various ruthenium bis(acetylacetonate) pyridine-imidazole complexes to nitroxyl radicals. Across these 36 reactions, the Δ and Δ can be independently varied, with different sets of Ru complexes primarily tuning either their ps or their °s.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!