AI Article Synopsis
- - The study focuses on human biliary tree stem/progenitor cells (hBTSC), which could be used for transplant in liver and pancreatic diseases, while also having the ability to influence immune responses through secretion molecules.
- - Researchers developed a new culture protocol to grow hBTSC in the lab, ensuring they maintain their stem cell characteristics and secretome profile, and examined what these cells secrete to understand their immune interaction.
- - Findings indicate that hBTSC produce hepatocyte growth factor, which can trigger apoptosis in human immune cells, suggesting their potential in regenerative medicine due to their ability to be stored, expanded, and secrete factors that regulate immune responses.
Article Abstract
Aim: Human biliary tree stem/progenitor cells (hBTSC) are multipotent epithelial stem cells with the potential for allogenic transplant in liver, biliary tree, and pancreatic diseases. Human mesenchymal stem cells, but also epithelial stem cells, are able to modulate immune responses with different types of secretion molecules.
Methods: The initial aim of the present study was to develop for the first time a culture protocol in order to expand hBTSC in vitro through passages, allowing to maintain a similar stem cell and secretome profile. Furthermore, we investigated the secretome profile of the hBTSC to assess the production of molecules capable of affecting immune feedback.
Results: We found that hepatocyte growth factor produced by hBTSC exerts its cytoprotective role inducing apoptosis in human immune cells, such as lymphocytes.
Conclusions: The present study, therefore, supports the hypothesis that hBTSC can be useful for the purpose of regenerative medicine, as they can be banked and expanded, and they can secrete immunoregulatory factors.
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| http://dx.doi.org/10.1111/hepr.12772 | DOI Listing |
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