Background: There are significant differences in the meaning and use of the term 'Reverse Innovation' between industry circles, where the term originated, and health policy circles where the term has gained traction. It is often conflated with other popularized terms such as Frugal Innovation, Co-development and Trickle-up Innovation. Compared to its use in the industrial sector, this conceptualization of Reverse Innovation describes a more complex, fragmented process, and one with no particular institution in charge. It follows that the way in which the term 'Reverse Innovation', specifically, is understood and used in the healthcare space is worthy of examination.
Methods: Between September and December 2014, we conducted eleven in-depth face-to-face or telephone interviews with key informants from innovation, health and social policy circles, experts in international comparative policy research and leaders in the Reverse Innovation space in the United States. Interviews were open-ended with guiding probes into the barriers and enablers to Reverse Innovation in the US context, specifically also informants' experience and understanding of the term Reverse Innovation. Interviews were recorded, transcribed and analyzed thematically using the process of constant comparison.
Results: We describe three main themes derived from the interviews. First, 'Reverse Innovation,' the term, has marketing currency to convince policy-makers that may be wary of learning from or adopting innovations from unexpected sources, in this case Low-Income Countries. Second, the term can have the opposite effect - by connoting frugality, or innovation arising from necessity as opposed to good leadership, the proposed innovation may be associated with poor quality, undermining potential translation into other contexts. Finally, the term 'Reverse Innovation' is a paradox - it breaks down preconceptions of the directionality of knowledge and learning, whilst simultaneously reinforcing it.
Conclusions: We conclude that this term means different things to different people and should be used strategically, and with some caution, depending on the audience.
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http://dx.doi.org/10.1186/s12992-016-0175-7 | DOI Listing |
J Thromb Haemost
January 2025
Dalla Lana School of Public Health, University of Toronto, Toronto, Canada; Office of the Vice-Principal of Research and Innovation, University of Toronto Mississauga, Mississauga, Canada. Electronic address:
Background: Whether to stop oral anticoagulants after a first unprovoked venous thromboembolism (VTE) is challenging, partially due to an intriguingly higher risk of VTE recurrence (rVTE) in men after therapy discontinuation. DNA methylation (DNAm) differences between men and women might underly this sex-biased rVTE risk difference.
Aim: To investigate sex-specific associations between DNAm at cytosine-phosphate-guanine (CpG) sites and rVTE.
Biomater Adv
January 2025
Zhejiang Sci-Tech University Shengzhou Innovation Research Institute, Shengzhou 312400, PR China.
Excessive oxidative stress and persistent inflammation are key factors contributing to the formation of diabetic chronic wounds. Delivering antioxidants through a microenvironment-responsive hydrogel system can effectively enhance wound healing and tissue regeneration. In this study, we developed a novel pH- and glucose-responsive hydrogel using Schiff base reaction and phenyl borate group for intelligent antioxidant release.
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January 2025
Gastric Cancer Center, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu Province, China. Electronic address:
Objective: The gut-brain axis (GBA) is involved in the modulation of multiple physiological activities, and the vagus nerve plays an important role in this process. However, the association between vagus nerve function and nutritional regulation remains unclear. Here, we explored changes in the nutritional status of mice after vagotomy and investigated the underlying mechanisms responsible for these changes.
View Article and Find Full Text PDFJ Colloid Interface Sci
January 2025
College of Energy, Soochow Institute for Energy and Materials Innovations, Soochow University, Suzhou 215006 China. Electronic address:
Lithium (Li) metal anodes hold great promise for next-generation secondary batteries with high energy density. Unfortunately, several problems such as Li dendrite growth, low Coulombic efficiency and poor cycle life hinder the commercialization of Li metal anodes. Herein, we design a highly lithiophilic carbon cloth host modified with Sn-doped zinc oxide (ZnO) (ZnSn-CC) directly derived from a bimetallic ZnSn metal-organic framework (ZnSn-MOF), which boosts uniform Li plating/stripping during charge-discharge and effectively protects the Li metal anode.
View Article and Find Full Text PDFChem Commun (Camb)
January 2025
Institute of Sustainability for Chemicals, Energy and Environment (ISCE2), Agency for Science, Technology and Research (A*STAR), 1 Pesek Road, Singapore 627833, Republic of Singapore.
Polymeric materials are ubiquitous in modern life. Similar to many other technological applications, polymer materials are essential in advancing the green hydrogen economy, offering solutions for hydrogen production, storage, transport, and utilization. In production, polymeric proton exchange membranes in water electrolysers enable efficient green hydrogen generation using renewable energy.
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