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Activation of human bitter taste receptors by polymethoxylated flavonoids. | LitMetric
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Activation of human bitter taste receptors by polymethoxylated flavonoids.

Yuki Kuroda Riko Ikeda Toyomi Yamazaki Keisuke Ito Kazunari Uda Keiji Wakabayashi Tatsuo Watanabe

Biosci Biotechnol Biochem

a Graduate School of Integrated Pharmaceutical and Nutritional Sciences , University of Shizuoka, Shizuoka , Japan.

Published: October 2016

Tangeretin and nobiletin are polymethoxylated flavonoids in citrus peel. Both tangeretin and nobiletin are bitter; however, their bitterness has not been evaluated using human bitter taste receptors (hTAS2Rs). We screened 25 kinds of hTAS2Rs and found that hTAS2R14 and hTAS2R46 received both compounds.

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http://dx.doi.org/10.1080/09168451.2016.1184558DOI Listing

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