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Relationships between the Regulatory Systems of Quorum Sensing and Multidrug Resistance. | LitMetric

Relationships between the Regulatory Systems of Quorum Sensing and Multidrug Resistance.

Front Microbiol

Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences Qingdao, China.

Published: July 2016

AI Article Synopsis

  • Quorum sensing (QS) is a form of cell-to-cell communication in bacteria, where signal molecules act like a chemical language, influencing behaviors and interactions both within and between species.
  • In Gram-negative bacteria, orphan LuxR receptors can detect a variety of signals, and in Gram-positive bacteria like Streptomyces, receptors respond to different antibiotics, indicating a complex interplay in communication and antibiotic production.
  • There’s potential evolutionary significance between QS systems and multidrug resistance (MDR) mechanisms, as both might share transport systems and interact in ways that could enhance our understanding of antimicrobial strategies.

Article Abstract

Cell-cell communications, known as quorum sensing (QS) in bacteria, involve the signal molecules as chemical languages and the corresponding receptors as transcriptional regulators. In Gram-negative bacteria, orphan LuxR receptors recognize signals more than just acylhomoserine lactones, and modulate interspecies and interkingdom communications. Whereas, in the Gram-positive Streptomyces, pseudo gamma-butyrolactones (GBLs) receptors bind antibiotics other than GBL signals, and coordinate antibiotics biosynthesis. By interacting with structurally diverse molecules like antibiotics, the TetR family receptors regulate multidrug resistance (MDR) by controlling efflux pumps. Antibiotics at subinhibitory concentration may act as signal molecules; while QS signals also have antimicrobial activity at high concentration. Moreover, the QS and MDR systems may share the same exporters to transport molecules. Among these orphan LuxR, pseudo GBL receptors, and MDR regulators, although only with low sequence homology, they have some structure similarity and function correlation. Therefore, perhaps there might be evolutionary relationship and biological relevance between the regulatory systems of QS and MDR. Since the QS systems become new targets for antimicrobial strategy, it would expand our understanding about the evolutionary history of these regulatory systems.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4909744PMC
http://dx.doi.org/10.3389/fmicb.2016.00958DOI Listing

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