There is a growing body of evidence indicating a crucial role of Exner's area in (hand-) writing symbolic codes such as letters and words. However, a recent study reported a patient with a lesion affecting Broca's and Exner's area, who suffered from severe peripheral agraphia for letters but not for Arabic digits. The authors suggested a speculative account postulating differential connectivity of Exner's area for numbers and letters in order to explain this dissociation. In the present study, we evaluated this account, employing atlas-based tractography for the patient's anatomy, deterministic fiber-tracking as well as an automated toolkit to investigate the connectivity of Exner's area in healthy adults. In particular, fiber pathways connecting Exner's area with areas associated with language processing (e.g., the arcuate fascicle, ventral pathways encompassing the external/extreme capsule system) reached the inferior part of Exner's area, while fronto-parietal fibers (e.g., the superior longitudinal fascicle) connected the upper part of Exner's area with the intraparietal sulcus typically involved in number processing. Our results substantiated the differential connectivity account for Exner's area by identifying the neural connections between fiber tracts and cortex areas of interest. Our data strongly suggest that white matter connectivity should be taken into account when investigating the neural underpinnings of impaired and intact human cognition.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4909732 | PMC |
| http://dx.doi.org/10.3389/fnhum.2016.00281 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Achieving room air quality of room class Ib in the aseptic area using a mobile sterile ventilation unit in a room class II surgical unit.
GMS Hyg Infect Control
December 2024
Institute of Hygiene and Environmental Medicine, University Medicine Greifswald, Germany.
Introduction: Room air class (RC) Ib may be necessary for surgical procedures in aseptic working areas. The aim of the study was to examine whether a mobile, three-stage sterile ventilation unit (MSVU) can replace a room ventilation system (RVS) with turbulent mixed flow (TMF) in the area of the operating field and on the instrument table from hygienic-microbiological point of view.
Method: During 26 surgeries (varicose vein stripping or treatment of umbilical and inguinal hernias), the microbial load was recorded at 4 measuring points (M1-M4) during regular operations by setting up sedimentation plates and measuring the particle concentration.
Rates of post procedural prophylactic antibiotic use following cardiac implantable electronic device insertion and the impact on surgical site infections in Alberta, Canada.
Antimicrob Resist Infect Control
December 2024
Department of Community Health Sciences, University of Calgary, Calgary, AB, Canada.
Background: The necessity of post procedural prophylactic antibiotics following clean surgeries is controversial. While most evidence suggests that there is no benefit from these additional antibiotics and guidelines do not support their use, there is a paucity of evidence as to how often they are still being used and their impact on infection outcomes. The current study assessed the use of prophylactic antibiotics following cardiac implantable electronic device (CIED) implantations in the province of Alberta, and their impact on infection and mortality.
View Article and Find Full Text PDFAssessing Therapeutic Nanoparticle Accumulation in Tumors Using Nanobubble-Based Contrast-Enhanced Ultrasound Imaging.
ACS Nano
December 2024
Department of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio 44106, United States.
Article Synopsis
- The study investigates challenges in delivering nanoparticle-based drugs to tumors, focusing on the inconsistent success of the enhanced permeability and retention (EPR) effect.
- It introduces a technique using multiparametric dynamic contrast-enhanced ultrasound (CEUS) with nanoscale contrast agents to noninvasively analyze tumor microenvironment features and predict the distribution and effectiveness of doxorubicin-laden liposomes.
- Results indicate that CEUS parameters, like area under the curve and decorrelation time, can accurately differentiate between tumors with varying vascular permeability, potentially serving as biomarkers for treatment responsiveness to nanoparticle therapies.
Reducing Distress from Auditory Verbal Hallucinations: A Multicenter, Parallel, Single-Blind, Randomized Controlled Feasibility Trial of Relating Therapy.
Psychother Psychosom
October 2024
Clinical Psychology and Psychotherapy, Institute of Psychology, Faculty of Psychology and Human Movement Science, Universität Hamburg, Hamburg, Germany.
Article Synopsis
- There is a high demand for effective treatments to reduce distress caused by auditory verbal hallucinations (AVHs), and this study explores the potential benefits of adding "Relating Therapy" (RT) to standard treatment.
- The study was conducted in Germany with 85 participants who struggled with AVHs, showing that RT combined with usual care led to high retention and adherence rates, indicating it is a feasible and safe intervention.
- Although the results don't show significant reductions in AVH distress compared to standard treatment alone, there were positive trends, suggesting further research on RT's efficacy is warranted.
The DMPTool NIH DMSP Templates Project.
J Med Libr Assoc
April 2024
Health Sciences Librarian, Medical Center Library, Saint Louis University, St. Louis, MO.
The DMPTool NIH Data Management and Sharing Plan (DMSP) Templates Project was launched in response to the 2023 NIH Data Management and Sharing (DMS) Policy. This new policy introduced a more structured framework for DMS Plans, featuring six key elements, a departure from the 2003 NIH DMS policy. The project aimed to simplify the process for data librarians, research administrators, and researchers by providing a template with curated guidance, eliminating the need to navigate various policies and guidelines.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!