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http://dx.doi.org/10.1016/j.jtcvs.2016.05.037 | DOI Listing |
Diagnostics (Basel)
December 2024
Department of Laboratory Medicine, Seoul National University Bundang Hospital and Seoul National University College of Medicine, Seoul 03080, Republic of Korea.
With advancements in molecular diagnostics, including Highly Multiplexed Microbiological/Medical Countermeasure Diagnostic Devices (HMMDs) and the impending integration of Next-Generation Sequencing (NGS) into clinical microbiology, interpreting the flood of nucleic acid data in a clinically meaningful way has become a crucial challenge. This study focuses on the Luminex xTAG Gastrointestinal Pathogen Panel (GPP) for detection, evaluating the impact of MFI threshold adjustments on diagnostic accuracy and exploring the need for an "indeterminate" result category to enhance clinical utility in molecular diagnostics. A retrospective review of -positive cases detected via the Luminex xTAG GPP was conducted from June 2016 to November 2023.
View Article and Find Full Text PDFCureus
November 2024
Division of Cardiovascular Surgery, Department of Surgery, Kurume University, Kurume, JPN.
The outcomes of cardiac surgery in patients with hematologic disorders are significantly worse. However, details of the clinical course of each hematologic disease remain unclear. Myelodysplastic syndrome (MDS) presents with progressive pancytopenia that has the risk of infection, hemorrhage, and transformation to acute myelogenous leukemia.
View Article and Find Full Text PDFJ Card Fail
December 2024
School of Nursing, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Background Delivering care that is responsive to who or what is most important to patients and family caregivers is a key aspect of quality care, yet it remains unclear how clinicians can best support individuals in expressing their personal values. We aimed to describe patient- and family caregiver-identified facilitators and barriers to engaging in values discussions with clinicians following implantation of a left ventricular assist device (LVAD). Methods and results Using a qualitative descriptive approach, patients with an LVAD and their caregivers participated in one-on-one semi structured interviews and self-reported sociodemographics (January 2023-July 2023).
View Article and Find Full Text PDFJMIR Form Res
December 2024
Department of Emergency Medicine, Yale School of Medicine, New Haven, CT, United States.
Background: Ischemic heart disease is a leading cause of death globally with a disproportionate burden in low- and middle-income countries (LMICs). Natural language processing (NLP) allows for data enrichment in large datasets to facilitate key clinical research. We used NLP to assess gender differences in symptoms and management of patients hospitalized with acute myocardial infarction (AMI) at Aga Khan University Hospital-Pakistan.
View Article and Find Full Text PDFCommun Med (Lond)
December 2024
Department of Biomedical Engineering, University of Connecticut, Storrs, CT, USA.
Background: Oxygen-rich breathing mixtures up to 100% are used in some underwater diving operations for several reasons. Breathing elevated oxygen partial pressures (PO) increases the risk of developing central nervous system oxygen toxicity (CNS-OT) which could impair performance or result in a seizure and subsequent drowning. We aimed to study the dynamics of the electrodermal activity (EDA) and heart rate (HR) while breathing elevated PO in the hyperbaric environment (HBO) as a possible means to predict impending CNS-OT.
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