AI Article Synopsis
- Atherosclerosis is a global health issue characterized by mitochondrial dysfunction, oxidative stress, and inflammation in affected patients.
- Nitric oxide plays a key role in this process, linking inflammatory and mitochondrial dysfunction and altering its bioavailability may increase heat shock protein expression.
- Understanding the mechanisms behind atherosclerosis can lead to new prevention strategies, including the use of functional foods and potential health interventions.
Article Abstract
Atherosclerosis, one of the main pathologic entities considered epidemic and a worldwide public health problem, is currently under constant review as regards its basic determining mechanisms and therapeutic possibilities. In this regard, all patients afflicted with the disease exhibit mitochondrial dysfunction, oxidative stress and inflammation. Interestingly, nitric oxide - a known vasoactive messenger gas - has been closely related to the inflammatory, oxidative and mitochondrial dysfunctional process that characterizes atherosclerosis. In addition, it has recently been demonstrated that alterations in the bioavailability of nitric oxide would induce the expression of heat shock proteins. This agrees with the use of functional foods as a strategy to prevent both vascular aging and the development of atherosclerosis. Finally, a greater knowledge regarding the mechanisms implied in the development of atherosclerosis will enable proposing new and possible hygiene, health and therapeutic interventions.
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| http://dx.doi.org/10.1016/j.arteri.2016.05.004 | DOI Listing |
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