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Deptor protects against myocardial ischemia-reperfusion injury by regulating the mTOR signaling and autophagy.
Cell Death Discov
December 2024
Department of Cardiology and Atrial Fibrillation Center, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
Deptor knockout mice were constructed by crossing Deptor Floxp3 mice with myh6 Cre mice, establishing a myocardial ischemia-reperfusion (I/R) model. Deptor knockout mice exhibited significantly increased myocardial infarction size and increased myocardial apoptosis in vivo. ELISA analysis indicated that the expression of CK-MB, LDH, and CtnT/I was significantly higher in the Deptor knockout mice.
View Article and Find Full Text PDFRecovery model for minimally invasive central cannulation, cardiopulmonary bypass, and cardioplegic arrest in quadrupeds.
Perfusion
December 2024
Department of Cardiac Surgery, University of Michigan Medical School, Ann Arbor, MI, USA.
Sternotomy is rarely performed for veterinary therapeutic or recovery models in quadrupeds because of difficulties with breathing, ambulation, and pain control. Central cannulation for cardiopulmonary bypass (CPB) is infrequent and typically performed through full thoracotomies. Experienced clinical surgeons and perfusionists should provide guidance for new therapeutic interventions and translational research.
View Article and Find Full Text PDFImpact of Mild Hypothermia As Adjunctive Therapy in Patients With ST-Elevation Myocardial Infarction: A Meta-Analysis and Trial Sequential Analysis of Randomized Controlled Trials.
Catheter Cardiovasc Interv
December 2024
Department of Translational Medicine, University of Eastern Piedmont, Novara, Italy.
Background: The prevention of reperfusion injury remains an unmet need in ST-elevation myocardial infarction (STEMI) patients. Several randomized controlled trials (RCTs) evaluated mild hypothermia as adjunctive therapy during STEMI, with conflicting results.
Aims: To summarize the evidence about the efficacy and safety of mild hypothermia in patients with STEMI, as well as its conclusiveness through a trial sequential analysis (TSA).
Free-Breathing Ungated Radial Simultaneous Multi-Slice Cardiac T1 Mapping.
J Magn Reson Imaging
December 2024
Utah Center for Advanced Imaging Research (UCAIR), Department of Radiology and Imaging Sciences, University of Utah, Salt Lake City, Utah, USA.
Background: Modified Look-Locker imaging (MOLLI) T1 mapping sequences are acquired during breath-holding and require ECG gating with consistent R-R intervals, which is problematic for patients with atrial fibrillation (AF). Consequently, there is a need for a free-breathing and ungated framework for cardiac T1 mapping.
Purpose: To develop and evaluate a free-breathing ungated radial simultaneous multi-slice (SMS) cardiac T1 mapping (FURST) framework.
Left Ventricular Systolic Function Changes During Pump-Assisted Beating Heart Coronary Artery Bypass Graft Surgery: A Prospective Observational Study.
Cureus
November 2024
Department of Cardiovascular and Thoracic Surgery, King George's Medical University, Lucknow, IND.
Background: There is a lack of information about the left ventricle (LV) systolic function changes during pump-assisted beating heart coronary artery bypass graft surgery (PACAB). This study aimed to study the changes in LV systolic function changes during PACAB.
Methods: In this prospective, single-arm, observational study, 70 patients with American Society of Anesthesiologists physical status III or IV of either sex, aged 40-70 years, scheduled to undergo elective PACAB for isolated ischemic heart disease with EF >30% were included.
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