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CD57 EMRA CD8 T cells in cancer patients over 70: associations with prior chemotherapy and response to anti-PD-1/PD-L1 therapy.
Immun Ageing
December 2024
Université Paris Cité, INSERM, PARCC, Paris, France.
Background: Immune ageing complicates cancer treatment in older individuals. While immunotherapy targeting the PD-1/PD-L1 pathway can reinvigorate T cells, these cells tend to become senescent with age. This study investigates different CD8 T cell subsets usually associated with senescence, in cancer patients over 70 years old who are undergoing anti-PD-1/PD-L1 immunotherapy, and examines the relationship between these senescent cells and prior chemotherapy exposure.
View Article and Find Full Text PDFThe influence of immune checkpoint blockade on the outcomes of allogeneic hematopoietic stem cell transplantation.
Front Immunol
December 2024
Senior Department of Hematology, the Fifth Medical Center of PLA General Hospital, Beijing, China.
Article Synopsis
- * Allogeneic hematopoietic stem cell transplant (allo-HCT) is the sole curative immunotherapy for certain blood cancers, but using ICIs before or after allo-HCT can lead to increased risks of severe complications such as graft-versus-host disease.
- * Ongoing research targets the challenge of combining ICIs with allo-HCT to maximize benefits while reducing side effects, emphasizing a need for better strategies in utilizing these immunotherapies for blood malignancies. *
Controllable All-in-One Biomimetic Hollow Nanoscaffold Initiating Pyroptosis-Mediated Antiosteosarcoma Targeted Therapy and Bone Defect Repair.
ACS Appl Mater Interfaces
December 2024
Department of Orthopedics, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230022, China.
Pyroptosis has gained attention for its potential to reinvigorate the immune system within the tumor microenvironment. However, current approaches employing pyroptosis inducers suffer from limitations. They primarily rely on single agents, lack precise targeting, and potentially disrupt the intricate bone formation microenvironment, hindering local repair of tumor-induced bone defects.
View Article and Find Full Text PDFAvoiding missed opportunities in AI for radiology.
Int J Comput Assist Radiol Surg
December 2024
Department of Radiology, Staten Island University Hospital - Northwell Health, 475 Seaview Avenue, Staten Island, NY, 10305, USA.
Purpose: In the last decade, the development of Deep Learning and its variants, based on the application of artificial neural networks, has reinvigorated Artificial Intelligence (AI). As a result, many new applications of AI in medicine, especially Radiology, have been introduced. This resurgence in AI, and its diverse clinical and nonclinical applications throughout healthcare, requires a thorough understanding to reap the potential benefits and avoid the potential pitfalls.
View Article and Find Full Text PDFA Claim of Conscience: The Duty to Prove Oneself a Resistor.
Linacre Q
May 2024
Social Research Area, Busch School of Business, The Catholic University of America, Washington, DC, USA.
An important question that arises as regards a member in a gravely unjust system is whether by any act of "resistance," undertaken at personal risk, he or she proved himself to be set against that system. This was the question posed by de-Nazification experts employed by the U.S.
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