Massive gastrointestinal bleeding in AIDS patients secondary to histoplasma and cytomegalovirus infection.

Int J Surg Case Rep

General Surgery Service, University Clinic Reina Fabiola, Catholic University of Córdoba, Oncativo 1248 street, Córdoba Capital, Argentina. Electronic address:

Published: August 2016

AI Article Synopsis

  • CMV can remain dormant in the body and reactivate when immunity is low, potentially causing serious health issues, especially in immunosuppressed patients.
  • Histoplasmosis typically affects the lungs but can appear in unusual areas, like the intestines, in those with weakened immune systems, sometimes leading to fatal outcomes.
  • A case of a 40-year-old man with AIDS is presented, suffering from severe lower gastrointestinal bleeding due to ulcers caused by both CMV and histoplasmosis, highlighting the rarity and complexity of diagnosing such conditions.

Article Abstract

Introduction: The Cytomegalovirus (CMV) is a virus that affects the host and remains latent. When cellular immunity is suppressed, the virus is reactivated and can cause an asymptomatic or devastating infection in immunosuppressed patients. On the other hand, Histoplasmosis is typically a respiratory condition. However, in immunosuppressed patients, it may be found in unusual locations, as in the case of an intestinal condition. In some cases, this can be fatal. Small intestine CMV location is extremely rare.

Case Presentation: 40-year-old man with AIDS presenting secondary massive lower gastrointestinal bleeding (MLGB) symptoms and ulcer granulomatous injuries located in the proximal ileum produced by the association of CMV and histoplasmosis.

Conclusion: Lower gastrointestinal bleeding diagnosis and treatment pose a challenge, considering the intestine extension and difficulties for its exploration. On the other hand, the association between Histoplasmosis and CMV as a massive gastrointestinal bleeding cause has not been described. There is no bibliography on the matter.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4930355PMC
http://dx.doi.org/10.1016/j.ijscr.2016.05.046DOI Listing

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