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Treadmill intervention attenuates motor deficit with 6-OHDA-induced Parkinson's disease rat via changes in lipid profiles in brain and muscle.
Aging (Albany NY)
January 2025
School of Nutrition and Health Sciences, College of Nutrition, Taipei Medical University, Taipei 11031, Taiwan.
One of the key hallmarks of Parkinson's disease is the disruption of lipid homeostasis in the brain, which plays a critical role in neuronal membrane integrity and function. Understanding how treadmill training impacts lipid restructuring and its subsequent influence on motor function could provide a basis for developing targeted non-pharmacological interventions for individuals living with early stage of PD. This study aims to investigate the effects of a treadmill training intervention on motor deficits induced by 6-OHDA in rats model of PD.
View Article and Find Full Text PDFCaloric depletion leads to behavioral changes that help an animal find food and restore its homeostatic balance. Hunger increases exploration and risk-taking behavior, allowing an animal to forage for food despite risks; however, the neural circuitry underlying this change is unknown. Here, we characterize how hunger restructures an animal's spontaneous behavior as well as its directed exploration of a novel object.
View Article and Find Full Text PDFDynamic changes in the hippocampal neuronal circuits activity following acute stress revealed by miniature fluorescence microscopy imaging.
Mol Brain
December 2024
Laboratory of Molecular Neurodegeneration, Peter the Great St. Petersburg Polytechnic University, Polytechnicheskaya St. 29, 195220, St. Petersburg, Russia.
Coordinated activity of neuronal ensembles is a basis for information processing in the brain. Recent development of miniscope imaging technology enabled recordings of neuronal circuits activity in vivo in freely behaving animals. Acute stress is believed to affect various hippocampal functions, especially memory.
View Article and Find Full Text PDFAnisodine hydrobromide injection promotes neural remodeling and recovery after ischemic stroke in mice.
Gen Physiol Biophys
November 2024
Department of Neurology, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, China.
Article Synopsis
- * The study tested anisodine hydrobromide on healthy male mice with induced middle cerebral artery occlusion, assessing its impact on neural growth and recovery using various staining techniques.
- * Results indicated that anisodine hydrobromide enhances nerve regeneration and synaptic formation, while the Notch signaling pathway plays a crucial role in its effects on neuroplasticity post-stroke.
Experience-driven development of decision-related representations in the auditory cortex.
EMBO Rep
January 2025
Department of Life Sciences, Ben-Gurion University of the Negev, 84105, Beer Sheva, Israel.
Associating sensory stimuli with behavioral significance induces substantial changes in stimulus representations. Recent studies suggest that primary sensory cortices not only adjust representations of task-relevant stimuli, but actively participate in encoding features of the decision-making process. We sought to determine whether this trait is innate in sensory cortices or if choice representation develops with time and experience.
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