Developmental research on spatial perspective taking has shown that young children are able to solve perspective-taking problems under favorable circumstances, but they have difficulties succeeding in classic tasks involving a conflict between one's own perspective and that of another observer. To date, little is known about the reasons for young children's difficulties in dealing with incongruent perspectives. Based on the assumption that one's own perspective has to be ignored to imagine someone else's perspective, it was investigated whether perspective taking is related to inhibitory control in 6-year-olds (N = 140). An adapted version of the 'Fruit Stroop task', appropriate for preschool children, was used to assess inhibitory control. Perspective taking was assessed using the 'Perspective-Taking Test for Children'. Other spatial and nonspatial abilities were assessed to investigate the specificity of the relation. Results showed a significant correlation between perspective taking and inhibitory control, even when controlled for age, verbal-IQ, and socio-economic status. However, no significant correlations between inhibition and other spatial abilities were found, indicating a specific relation between inhibition and perspective taking. A linear regression analysis showed that, even after accounting for effects of control variables as well as other mental transformation abilities, inhibition accounted for a significant part of the variance in perspective-taking performance. The present findings provide valuable information on what contributes to individual differences in perspective taking, which is an important aspect of everyday cognition and bears relevance for reasoning in technical domains.
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http://dx.doi.org/10.1007/s00426-016-0785-y | DOI Listing |
Adv Sci (Weinh)
December 2024
CAS Engineering Laboratory for Nanozyme, Key Laboratory of Protein and Peptide Pharmaceutical Institute of Biophysics, Chinese Academy of Sciences, Beijing, 100101, P. R. China.
Owing to their attractive antitumor effects, aminated fullerene derivatives are emerging as promising therapeutic drugs for cancer. However, their in vivo applications are severely limited due to cation toxicity. To address this problem, human heavy chain ferritin (HFn), possessing natural biocompatibility is utilized, to develop a novel supramolecular assembly drug delivery system.
View Article and Find Full Text PDFBrief Bioinform
November 2024
Institute of Medical Information, Chinese Academy of Medical Sciences and Peking Union Medical College, Chaoyang District, Beijing 100020, China.
Drug resistance in Mycobacterium tuberculosis (Mtb) is a significant challenge in the control and treatment of tuberculosis, making efforts to combat the spread of this global health burden more difficult. To accelerate anti-tuberculosis drug discovery, repurposing clinically approved or investigational drugs for the treatment of tuberculosis by computational methods has become an attractive strategy. In this study, we developed a virtual screening workflow that combines multiple machine learning and deep learning models, and 11 576 compounds extracted from the DrugBank database were screened against Mtb.
View Article and Find Full Text PDFFront Immunol
December 2024
German Cancer Consortium (DKTK), Partner site Frankfurt/Mainz, a partnership between DKFZ and University Medical Center Frankfurt, Frankfurt, Germany.
Introduction: Posttransplant cyclophosphamide (PTCy) has revolutionized the landscape of human leukocyte antigen (HLA)-haploidentical hematopoietic cell transplantation (haplo-HCT), providing a pivotal therapeutic option for patients with hematological malignancies who lack an HLA-matched donor.
Methods: In this retrospective analysis involving 54 adult patients undergoing PTCy-based haplo-HCT, we evaluated the impact of inhibitory killer immunoglobulin-like receptor (KIR)/HLA mismatch, alongside patient, donor, and transplant factors, on clinical outcomes within a homogeneous cohort characterized by a myeloablative conditioning regimen and bone marrow graft.
Results: With a median follow-up of 73.
Cytojournal
November 2024
Department of Ultrasound, The Third Xiangya Hospital of Central South University, Changsha, China.
Objective: Thyroid cancer (TC) therapy, which is routinely used at present, can improve patients' survival rates. However, lymph node metastasis results in a higher degree of TC malignancy in patients who experience recurrence and/or death. The elucidation of new mechanisms of TC metastasis can help identify new therapeutic targets.
View Article and Find Full Text PDFMicrob Pathog
December 2024
Faculty of Veterinary Medicine, Federal University of Uberlândia, Uberlândia, 38402-018, Brazil.
Silver nanoparticles are recognized for potent antimicrobial properties against pathogenic bacteria, crucial in addressing the severity of leptospirosis, where an ideal treatment is lacking. This study focuses on assessing the antimicrobial efficacy of silver-doped zinc oxide nanoparticles (ZnO:9Ag) on standard Leptospira spp. strains (six species and ten serovars).
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