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Arguments against a "general and permanent" ban on pediatric intersex surgery: A response to Clune-Taylor.
Bioethics
January 2025
Institute of Social Sciences, Centre for Sociological and Anthropological Research, Belgrade, Serbia.
The paper offers a critical response to the proposed "dis/analogy" between the restriction of Jehovah's Witness parental right to refuse life-saving blood transfusions for their minor children and a "general" and "permanent" ban on "unnecessary" pediatric intersex surgery. The main argument of the analogy is "securing the patient's future autonomy." Feinberg's theory of rights is used to demonstrate that the proposed analogy is untenable.
View Article and Find Full Text PDFSecond Generation Antipsychotics and Cardiovascular Adverse Effects: Developing Evidence-Based Recommendations for Primary Care Medicine.
HCA Healthc J Med
December 2024
Heritage Valley Health System, Beaver Falls, PA.
Background: Second-generation antipsychotic medications (SGAs) are often used by primary care physicians (PCPs) to treat multiple psychiatric diagnoses. SGAs have been connected to a number of adverse effects, including cardiovascular disease. Currently, there are no published evidence-based recommendations addressing SGAs and cardiotoxicity that are directed toward PCPs.
View Article and Find Full Text PDFCo-activating STING-TLR9 pathways promotes radiotherapy-induced cancer vaccination.
J Control Release
January 2025
College of Pharmaceutical Sciences, College of Chemistry, Chemical Engineering and Materials Science,, Soochow University, Suzhou 215123, People's Republic of China; State Key Laboratory of Radiation Medicine and Protection, Soochow University, Suzhou 215123, People's Republic of China. Electronic address:
Vaccination may cure cancer patients by inducing tumor-specific immune responses. Radiotherapy is an appealing strategy to generate cancer vaccines in situ; thus far, however, only modest and short-lived immune responses are achieved. We here show that radiation combined with co-activating STING-TLR9 can generate powerful in situ cancer vaccines.
View Article and Find Full Text PDFRelating Photoperiod and Outdoor Temperature With Sleep Architecture in Patients With Neuropsychiatric Sleep Disorders.
J Pineal Res
January 2025
Institute of Physiology, Sleep Research & Clinical Chronobiology, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.
While artificial light in urban environments was previously thought to override seasonality in humans, recent studies have challenged this assumption. We aimed to explore the relationship between seasonally varying environmental factors and changes in sleep architecture in patients with neuropsychiatric sleep disorders by comparing two consecutive years. In 770 patients, three-night polysomnography was performed at the Clinic for Sleep & Chronomedicine (St.
View Article and Find Full Text PDFObservations on the Etiology of Involutional Entropion.
Ophthalmic Plast Reconstr Surg
December 2024
John F. Hardesty, MD, Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St. Louis, Missouri, U.S.A.
Purpose: To review evidence supporting proposed anatomic etiologies of involutional entropion and propose additional potential contributing factors.
Methods: A literature review was performed to identify publications describing possible etiologies of involutional entropion. The author's clinical observations and information supporting new proposed causes are presented.
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