It is important to realize that guidelines cannot always account for individual variation among patients. They are not intended to supplant physician judgment with respect to particular patients or special clinical situations. IDSA considers adherence to these guidelines to be voluntary, with the ultimate determination regarding their application to be made by the physician in the light of each patient's individual circumstances.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4967602PMC
http://dx.doi.org/10.1093/cid/ciw326DOI Listing

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