This study addresses the relationship between information structure and intonation in French. Using an interactive speech production experiment, it tests the hypothesis that the French initial rise (LHi) is used to mark the left edge of a contrastively focused constituent. Since the occurrence of the initial rise is also known to be sensitive to the length of an Accentual Phrase (AP), AP length was manipulated within the same experiment in a 2 x 2 design. This made it possible to explore the issue of whether the initial rise represents a true marker of focus in the traditional sense, or whether the association is less direct. The results show that focus and phrase length make contributions to the distribution of the initial rise, but with no interaction. It is argued that these findings are incompatible with a model that assumes a direct mapping between focus and the initial rise, and that the relatively weak association can nevertheless be informative in a model of interpretation that integrates multiple probabilistic inputs to initial rise occurrence. These findings represent the first quantitative experimental assessment of focus realization in French in a non-corrective context, and establish a previously undocumented link between the initial rise and discourse-level meaning.
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Cancer Discov
March 2025
University of California, San Francisco, San Francisco, CA, United States.
Historical studies performed nearly a century ago using mouse skin models identified two key steps in cancer evolution: initiation, a likely mutational event, and promotion, driven by inflammation and cell proliferation. Initiation was proposed to be permanent, with promotion as the critical rate-limiting step for cancer development. Here, we carried out whole genome sequencing to demonstrate that initiated cells with thousands of mutagen-induced mutations can persist for long periods and are not removed by cell competition or by immune intervention, thus mimicking the persistence of cells with cancer driver mutations in normal human tissues.
View Article and Find Full Text PDFPLoS One
March 2025
Yunnan Province Engineering Research Center for Functional Flower Resources and Industrialization, Southwest Forestry University, Kunming, Yunnan, China.
Rhus chinensis, a native plant species of China, possesses significant economic value in the ornamental sector. This study investigates the floral fragrance components and release patterns of R. chinensis, thus providing a theoretical foundation for the utilization of its floral fragrance.
View Article and Find Full Text PDFUrologia
March 2025
Division of Urology, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada.
Objective: To compare trends and incidence of surgical intervention among adults with urolithiasis in Ontario, Canada, and Israel.
Patients And Methods: A retrospective analysis was conducted using administrative databases from Clalit Health Service in Israel and IC/ES in Canada. The study included adults who underwent their initial surgical treatment for urolithiasis.
The global rise of end-stage renal disease is leading to an increase in kidney transplants. Graft survival is dependent on the occurrence of inflammation which can lead to cases of rejection. Traditional laboratory analyses often lack accuracy, and graft biopsies - the current gold standard - are considered invasive and risky.
View Article and Find Full Text PDFCureus
February 2025
Gastroenterology and Hepatology, Baylor Scott & White All Saints Medical Center, Fort Worth, USA.
Intraductal papillary mucinous neoplasms (IPMNs) are a prevalent subtype of pancreatic cystic lesions, especially among individuals with liver cirrhosis. Intraductal papillary neoplasms of the bile duct (IPNBs) differ in histopathology based on the location and cellular variability in each location. Intrahepatic IPNBs are less aggressive than the extrahepatic variant, highlighting its heterogeneity and complexity.
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