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Brain aging rejuvenation factors in adults with genetic and sporadic neurodegenerative disease.
Brain Commun
January 2025
Department of Neurology, Memory and Aging Center, University of California, San Francisco, CA 94158, USA.
The largest risk factor for dementia is age. Heterochronic blood exchange studies have uncovered age-related blood factors that demonstrate 'pro-aging' or 'pro-youthful' effects on the mouse brain. The clinical relevance and combined effects of these factors for humans is unclear.
View Article and Find Full Text PDFMulti-Objective Optimization Accelerates the De Novo Design of Antimicrobial Peptide for .
Int J Mol Sci
December 2024
Department of Chemical Engineering & Institute of Biotechnology Engineering and Chemical Engineering, I-Shou University, Kaohsiung 824005, Taiwan.
Humans have long used antibiotics to fight bacteria, but increasing drug resistance has reduced their effectiveness. Antimicrobial peptides (AMPs) are a promising alternative with natural broad-spectrum activity against bacteria and viruses. However, their instability and hemolysis limit their medical use, making the design and improvement of AMPs a key research focus.
View Article and Find Full Text PDFCyanobacteria in winter: Seasonal dynamics of harmful algal blooms and their driving factors in boreal lakes.
Heliyon
December 2024
Groupe de Recherche en Écologie de la MRC Abitibi (GREMA), Institut de Recherche sur les Forêts, Université du Québec en Abitibi-Témiscamingue, 341 Rue Principale N, Amos, QC, J9T 2L8, Canada.
Lake cyanobacteria can overgrow and form blooms, often releasing life-threatening toxins. Harmful algal blooms (HABs) are typically caused by excess nutrients and high temperatures, but recent observations of cyanobacteria beneath the ice in boreal lakes suggest that the dynamics are more complex. This study investigates the seasonal dynamics of HABs in boreal lakes and identifies their driving factors.
View Article and Find Full Text PDFThe Role of Visual and Chemosensory Signals in Male-Male Aggression of the Cichlid Astatotilapia burtoni.
Aggress Behav
January 2025
Department of Biological Sciences, Louisiana State University, Baton Rouge, Louisiana, USA.
Sensory processing of communication stimuli is essential for the survival of organisms across all evolutionary branches. Multimodal signaling, the use of multiple sensory systems is crucial in this process, but little is known about the relative importance of different senses used during aggression. We used the African cichlid fish, Astatotilapia burtoni, to test how visual and chemosensory signals in male-male interactions influence behavior.
View Article and Find Full Text PDFNitrous oxide is the main product during nitrate reduction by a novel lithoautotrophic iron(II)-oxidizing culture from an organic-rich paddy soil.
Appl Environ Microbiol
December 2024
Geomicrobiology, Department of Geosciences, University of Tübingen, Tübingen, Germany.
Microbial nitrate reduction coupled to iron(II) oxidation (NRFeOx) occurs in paddy soils due to high levels of dissolved iron(II) and regular application of nitrogen fertilizer. However, to date, there is no lithoautotrophic NRFeOx isolate or enrichment culture available from this soil environment. Thus, resulting impacts on greenhouse gas emissions during nitrate reduction (i.
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