AI Article Synopsis
- The "G3-Xantphos" palladacycle pre-catalyst achieves high-yield functionalization of cysteine-containing peptides.
- The bioconjugation process is chemoselective and operates effectively at room temperature, ensuring biocompatibility.
- This approach can also be applied to protein functionalization, including the selective bioconjugation of the trastuzumab antibody.
Article Abstract
The third generation of aminobiphenyl palladacycle pre-catalyst "G3-Xantphos" enables functionalization of peptides containing cysteine in high yields. The conjugation (bioconjugation) occurs chemoselectively at room temperature under biocompatible conditions. Extension of the method to protein functionalization allows selective bioconjugation of the trastuzumab antibody.
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| http://dx.doi.org/10.1002/chem.201602277 | DOI Listing |
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