AI Article Synopsis
- The study reports a rare occurrence of Enterobacteriaceae with IMP-4 or IMP-8 carbapenemases in a Chinese hospital over two years, mainly affecting patients in the ICU with severe illnesses.
- Genetic analysis revealed distinct patterns among different strains, with many patients effectively treated and discharged.
- The findings emphasize the need for vigilant screening and rapid identification of these antibiotic-resistant strains to prevent outbreaks in healthcare settings.
Article Abstract
Background: The emergence of Enterobacteriaceae harboring IMP-4 or IMP-8 carbapenemases is rare. We report an occurrence of Enterobacteriaceae harboring IMP-4 or IMP-8 carbapenemases in a Chinese tertiary care hospital from November 2010 to December 2012.
Methods: The clinical characteristics of 30 patients were described. The genetic relationship of isolates was determined by pulsed-field gel electrophoresis (PFGE). Carbapenemases were detected by modified Hodge test (MHT) and polymerase chain reactions (PCRs). Amplicons were sequenced and blasted to determine the genotype.
Results: Most infected patients were from intensive care unit and had complex and serious underlying illnesses requiring mechanical ventilation. PFGE revealed that Klebsiella pneumoniae showed two major PFGE types. Two Klebsiella oxytoca had an indistinguishable PFGE pattern, while four Enterobacter cloacae were different strains. The sequencing studies showed Enterobacteriaceae harboring IMP-4 or IMP-8 carbapenemase in the 23 infected patients. The majority of patients had infections with the carbapenemase-producing Enterobacteriaceae (CPE) strain, most were successfully treated with a range of antibiotics and discharged.
Conclusion: It is important to maintain a high index of suspicion to screen for carbapenemase-producing Enterobacteriaceae strains. Rapid identification of these strains and implementation of stringent procedures are the key to prevent major outbreaks in a hospital setting.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4915421 | PMC |
| http://dx.doi.org/10.4314/ahs.v16i1.21 | DOI Listing |
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