Kawasaki disease is an acquired vasculitis that can affect the coronary arteries placing the patient at risk for coronary artery thrombosis, myocardial ischemia and infarction. The risk of complications related to coronary artery involvement persists for years despite recovery from the acute illness phase. The risk of late coronary disease progression necessitates long term follow-up generally accomplished by non-invasive echocardiography in pediatric patients. We review the utility of echocardiography in patients with Kawasaki disease as it relates to initial management, risk stratification and follow-up of these children.
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Associations of infection burden with Kawasaki disease in a population-based setting during 30 years.
RMD Open
January 2025
Department of Medicine, Karolinska Institutet, Stockholm, Sweden
Objectives: The objective of this study was to investigate the role of infections in the pathogenesis of Kawasaki disease.
Methods: The investigation was a nationwide epidemiological case-control study, comprising all cases of Kawasaki disease diagnosed in Sweden 1987-2018. Controls were randomly sampled from the general population, matched on sex, age, and area of residency.
Risk of Kawasaki Disease/Multisystem Inflammatory Syndrome Following COVID-19 Vaccination in Korean Children: A Self-Controlled Case Series Study.
J Korean Med Sci
January 2025
School of Pharmacy, Sungkyunkwan University, Suwon, Korea.
Background: Rare cases of Kawasaki disease (KD) and multisystem inflammatory syndrome in children (MIS-C) have been reported following the coronavirus disease 2019 (COVID-19) vaccination; however, the association between COVID-19 vaccination and the risk of developing KD/MIS-C has not yet been established.
Methods: We conducted a self-controlled case series analysis using a large-linked database that connects the COVID-19 immunization registry with nationwide claims data. We identified individuals aged < 18 years who received their initial COVID-19 vaccination and had a KD/MIS-C diagnosis with a prescription for intravenous immunoglobulin or corticosteroids between October 18, 2021, and April 15, 2023.
Association of respiratory infections with the incidence and treatment efficacy in Kawasaki disease.
Diagn Microbiol Infect Dis
January 2025
Department of Pediatrics, Nara Prefecture General Medical Center, Nara, Japan.
The etiology of Kawasaki disease (KD) has not yet been completely elucidated. We evaluated the temporal association between respiratory pathogens and KD incidence and the association between respiratory pathogens and treatment responsiveness in patients with KD. This retrospective study was conducted to compare the number of symptomatic children with pathogens detected using multiplex PCR tests with the number of KD cases.
View Article and Find Full Text PDFCoronary complications in Kawasaki disease: giant aneurysms and thrombosis leading to myocardial infarction.
Eur Heart J Imaging Methods Pract
January 2025
Eighth Floor Hospitalization, National Institute of Cardiology: Instituto Nacional de Cardiologia, Juan Badiano 1, Belisario Domínguez Secc 16, Tlalpan, Mexico City, Mexico 14080, Mexico.
Systemic artery aneurysms - A marker of high-risk Kawasaki disease.
Ann Pediatr Cardiol
December 2024
Department of Cardiovascular Radiology and Endovascular Interventions, All India Institute of Medical Sciences, Delhi, India.
Kawasaki disease, traditionally classified as medium vessel vasculitis, is known for the preferential involvement of coronary arteries. Infrequently, large systemic arteries might be involved and may affect the prognosis. Here, we present an infant with Kawasaki disease who had extensive involvement of large vessels such as the abdominal aorta and medium vessels of the extremities, along with giant coronary artery aneurysms.
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