AI Article Synopsis
- The study examines the characteristics and treatments of brain metastasis in patients with gynecologic cancers, focusing on 23 cases from 2008 to 2012.
- Most patients had cervical (5), endometrial (8), or ovarian cancer (10), with symptoms like headache being common; 91.3% had central nervous system symptoms.
- While treatment types (surgery, radiotherapy, chemotherapy) didn't improve survival rates significantly, chemotherapy did enhance survival for patients with additional extracranial metastasis.
Article Abstract
Objective: To explore the clinicopathological characteristics and treatments of brain metastasis (BM) in patients with gynecologic carcinoma.
Methods: Twenty-three pathologically confirmed patients with gynecologic carcinoma who had brain metastasis between February 2008 and October 2012 were analyzed retrospectively.
Results: The primary carcinoma was cervical cancer in 5 patients, endometrial carcinoma in 8 patients and ovarian cancer in 10 patients, which accounted for 1.81% (5/276), 2.10% (8/380) and 2.67% (10/374) of patient with the same diagnosis of the same period, respectively.Among them, 91.3% (21/23) patients had heterochronous BM.Single BM was documented in 52.2% (12/23) patients.Besides, 78.2% (18/23) BM located in cerebrum.At the time of BM, 91.3% (21/23) patients had symptoms of central nervous system, in which headache ranked the top (90.4%). Altogether, thirteen patients had extracranial metastasis, in which 9 of them had metastasis of the lung.The median post-brain-metastasis survival (mPBMS) for the recursive partitioning analysis (RPA) classes Ⅰ-Ⅲ was 54 months, 9 months and 1 month, respectively (P<0.01). None of surgery, radiotherapy or chemotherapy treatment was proven to have prognosis-improving ability either in single variant or multivariate analysis.However, in patients with extracranial metastasis, chemotherapy could significantly improve their mPBMS (P<0.05).
Conclusions: The incidence of brain metastasis in patients with cervical cancer, endometrial carcinoma, and ovarian cancer increased gradually.RPA was valuable for a prognostic assessment in gynecologic carcinoma patients with BM.Chemotherapy could significantly improve prognosis of gynecologic carcinoma patients with BM if extracranial metastasis was presented.
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| http://dx.doi.org/10.3760/cma.j.issn.0376-2491.2016.23.012 | DOI Listing |
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