AI Article Synopsis
- Nosocomial infections are prevalent in African hospitals, especially in neonatal units, often caused by bacteria like E. coli and Klebsiella, with rare involvement of Salmonella.
- The study reports the first cases of Salmonella Grumpensis in neonatal infections in Senegal, isolating 17 strains from hospitalized infants.
- Most strains exhibited antibiotic resistance, including the presence of the blaCTX-M-109 gene, and all 13 analyzed strains were found to be genetically identical.
Article Abstract
Nosocomial infections are very common in African hospitals, particularly in neonatal units. These infections are most often caused by bacteria such as Escherichia coli, Klebsiella spp and Staphylococcus spp. Salmonella strains are rarely involved in nosocomial infections. Here, we report the first description of S. Grumpensis in neonatal infections in Senegal. Seventeen Salmonella strains were isolated from hospitalized infants' stool samples. The following resistance phenotype was described in strains: AMXRTICRCFR FOXRCFXRCTXRCAZRIMPSATMRNARNORRCIPRTMRGMRTERSXTR. All isolates were susceptible to imipenem, 15 out of 17 produced an extended spectrum ß-lactamase (ESBL). blaOXA-1, blaSHV-1, blaTEM-1, blaCTX-M1 genes were detected in strains 8, 13, 5 and 8, respectively. blaCTX-M1 sequencing revealed the presence of blaCTX-M-109. Thirteen of the 17 Salmonella Grumpensis strains were analyzed by PFGE. These 13 isolates belonged to a single pulsotype and were genotypically identical. This is the first report of neonatal S. Grumpensis infections in Senegal, and the first report of blaCTX-M-109 in the genus Salmonella.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4927072 | PMC |
| http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0157683 | PLOS |
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