AI Article Synopsis
- - The study evaluated the significance of the Melanoma cell adhesion molecule (MCAM) as a marker for endothelial damage in chronic heart failure (CHF) patients, involving 130 patients and 32 controls over a year of follow-up.
- - Results showed that MCAM levels were significantly higher in CHF patients compared to controls, indicating it could potentially predict mortality risk, with higher levels correlating with poorer outcomes.
- - The findings suggest that elevated MCAM could serve as an important prognostic marker in CHF, alongside other factors like NT-proBNP and age.
Article Abstract
Background: Melanoma cell adhesion molecule (MCAM) is a marker of endothelial damage. MCAM diagnostic and prognostic value was assessed in chronic heart failure (CHF).
Materials & Methods: 130 CHF patients and 32 controls were included in the study. Telephone follow-up lasted one year. End points were: death from all causes, and hospitalization with CHF exacerbation.
Results: MCAM was higher in patients than in controls (p = 0.01). Receiver operator curve analysis revealed that MCAM may serve as a predictor of death (area under the curve: 0.8404; p < 0.002). Patients with MCAM above 500 ng/ml had worse prognosis (p = 0.03). NT-proBNP and age were independent predictors of death in multivariate analysis.
Conclusion: The increased MCAM indicates endothelial damage in CHF and may serve as a marker of worse prognosis in these patients.
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| http://dx.doi.org/10.2217/bmm-2016-0053 | DOI Listing |
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