AI Article Synopsis
- - Sphingosine 1-phosphate (S1P) is a lipid derived from ceramide that acts as a key signaling molecule, particularly in immune responses, by activating specific G-protein-coupled receptors (S1P1-5).
- - Activation of these receptors influences various processes like cell proliferation, survival, migration, and can even promote new blood vessel formation (angiogenesis).
- - The review will explore S1P's involvement in lymphocyte movement, inflammation, infection, and cancer, as well as its potential for therapeutic targeting in treating these conditions.
Article Abstract
Sphingosine 1-phosphate (S1P) is a sphingosine containing lipid intermediate obtained from ceramide. S1P is known to be an important signaling molecule and plays multiple roles in the context of immunity. This lysophospholipid binds and activates G-protein-coupled receptors (GPCRs) known as S1P receptors 1-5 (S1P1-5). Once activated, these GPCRs mediate signaling that can lead to alterations in cell proliferation, survival or migration, and can also have other effects such as promoting angiogenesis. In this review, we will present evidence demonstrating a role for S1P in lymphocyte migration, inflammation and infection, as well as in cancer. The therapeutic potential of targeting S1P receptors, kinases and lyase will also be discussed.
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Source |
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5985508 | PMC |
| http://dx.doi.org/10.1093/femspd/ftw063 | DOI Listing |
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