AI Article Synopsis

  • This study compared the safety and effectiveness of a new intra-articular viscosupplement called HAnOX-M, made from intermediate molecular weight hyaluronic acid and mannitol, against a standard high molecular weight hyaluronic acid (Bio-HA) in patients with knee osteoarthritis.
  • The trial involved 205 patients who received three injections of either HAnOX-M or Bio-HA, with results primarily assessed through changes in the WOMAC pain scale after six months, showing non-inferiority between the two treatments.
  • Both treatments significantly reduced knee pain and improved joint function, indicating that HAnOX-M is as effective and safe as the conventional HA treatment for alleviating knee OA symptoms.*

Article Abstract

Background: To compare both safety and efficacy of a novel intra-articular viscosupplement made of intermediate molecular weight (MW) hyaluronic acid (HA) mixed with high concentration of mannitol with a marketed high MW HA, in patients with knee osteoarthritis (OA).

Methods: Patients with symptomatic knee OA, with radiological OARSI grades 1 to 3, were enrolled in a controlled, double-blind, parallel-group, non-inferiority trial. They were randomized to receive three intra-articular injections, at weekly intervals, of either HAnOX-M made of a combination of HA (MW one to 1.5MDa, 31mg/2ml) and mannitol (70mg/2ml) or Bio-HA (MW 2.3 to 3.6MDa, 20mg/2ml). The primary outcome was six-month change in the WOMAC pain subscale (0 to 20). Sample size was calculated according to a non-inferiority margin of 1.35. Secondary endpoints included six-month change in function and walking pain, analgesic consumption and safety.

Results: The intention-to-treat (ITT) and per-protocol (PP) populations consisted of 205 and 171 patients. HAnOX-M and Bio-Ha groups did not differ statistically at baseline. The primary analysis was conducted in the PP population, then in the ITT population. The average WOMAC pain score at baseline was 9.5 in both groups. Mean (SD) variations in WOMAC pain score were -4.4 (3.8) and -4.5 (4.3) mm, for HAnOX and Bio-HA respectively, satisfying the claim for non-inferiority. Similar results were obtained for all other secondary endpoints.

Conclusion: Treatment with of HAnOX-M is effective to alleviate knee OA symptoms and to improve joint function over six months, with similar safety than conventional HA viscosupplement.

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.knee.2016.05.015DOI Listing

Publication Analysis

Top Keywords

womac pain
12
safety efficacy
8
intra-articular injections
8
hyaluronic acid
8
patients symptomatic
8
symptomatic knee
8
knee osteoarthritis
8
six-month change
8
pain score
8
efficacy intra-articular
4

Similar Publications

Objective: Osteoarthritis (OA), particularly knee OA, affects 24% of adults and is a significant cause of disability. Nonsteroidal anti-inflammatory drugs (NSAIDs) are commonly used but have many adverse effects. Antioxidant and anti-iflammatory properties of might decrease pain thus improving joint function.

View Article and Find Full Text PDF

Validation of the Portuguese Version of the Modified Harris Hip Score Questionnaire - HHSmBr.

Rev Bras Ortop (Sao Paulo)

December 2024

Grupo de Quadril, Departamento de Ortopedia e Traumatologia, Faculdade de Ciências Médicas da Santa Casa de Misericórdia de São Paulo (FCMSCSP), São Paulo, SP, Brasil.

 To validate the Portuguese version of the evaluation instrument modified Harris Hip Score.  The modified Harris Hip Score went through a validation process for the Portuguese language. We tested the measurement properties of the Brazilian Portuguese version of the modified Harris Hip Score (HHSmBr) on 100 patients (63% females and 37% males) with different hip conditions.

View Article and Find Full Text PDF

Efficacy of Genicular Nerve Block in Patients with Osteoarthritis: A Comparative Study with and without Fluoroscopy Assistance.

Rev Bras Ortop (Sao Paulo)

December 2024

Grupo do Joelho e Artroscopia, Departamento de Ortopedia e Traumatologia, Escola Paulista de Medicina, Universidade Federal de São Paulo (Unifesp), São Paulo, SP, Brasil.

 To compare the efficacy of fluoroscopy as an auxiliary method in genicular nerve block (GNB) with block guidance by anatomical parameters, without imaging aid, in reducing pain.  A total of 23 patients underwent fluoroscopy-guided or anatomical parameter-based GNBs. We applied the Western Ontario and McMaster Universities' Osteoarthritis Index (WOMAC) and the Visual Analog Scale (VAS) for pain at 6 time points (preblock, and after 1 hour, 24 hours, 7 days, 28 days, and 90 days).

View Article and Find Full Text PDF

Associations between bone mineral density and WOMAC scores in healthy individuals: Insights from the Qatar Biobank.

J Clin Densitom

November 2024

Department of Biomedical Sciences, College of Health Sciences, QU Health, Qatar University, Doha, 2713, Qatar. Electronic address:

Background: Bone mineral density (BMD) is an indicator of bone health that predicts future bone fractures. The Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) is used to assess the severity of symptoms related to pain, stiffness, and function in diseased hip and knee joints. Here we assessed whether BMD measured at specific sites predicts WOMAC scores in healthy individuals whilst controlling for sociodemographic variables.

View Article and Find Full Text PDF

Background: Accumulating evidence suggests that the radiographic phenotypes of patients with knee osteoarthritis (KOA) often do not correlate with their clinical findings, which are the primary reason for seeking medical care. Therefore, at OARSI 2024, we proposed a clinical finding staging system-Chinese medicine staging (CMS)-to guide the treatment of KOA. However, the clinical effectiveness and application characteristics of CMS in guiding non-surgical treatment of KOA remain unclear.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!

A PHP Error was encountered

Severity: Notice

Message: fwrite(): Write of 34 bytes failed with errno=28 No space left on device

Filename: drivers/Session_files_driver.php

Line Number: 272

Backtrace:

A PHP Error was encountered

Severity: Warning

Message: session_write_close(): Failed to write session data using user defined save handler. (session.save_path: /var/lib/php/sessions)

Filename: Unknown

Line Number: 0

Backtrace: