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Obesity and insulinopenic type 2 diabetes differentially impact, bone phenotype, bone marrow adipose tissue, and serum levels of the cathelicidin-related antimicrobial peptide in mice.
Bone
December 2024
Marrow Adiposity and Bone Lab, MABLab-ULR4490, Univ. Littoral Côte d'Opale F-62200 Boulogne-sur-Mer, Univ. Lille F-59000 Lille, CHU Lille, F-59000 Lille, France. Electronic address:
Article Synopsis
- Obesity can lead to systemic inflammation and insulin resistance, increasing the risk of type 2 diabetes (T2D) and negatively impacting bone health, with unclear differences in effects between obesity and T2D.
- The study aimed to investigate how hyperinsulinemic obesity and insulinopenic T2D affect bone structure and bone marrow adipose tissue (BMAT), while also exploring the relationship with CRAMP expression and levels.
- Mice fed a high-fat diet exhibited significant weight gain and bone deterioration, while those with insulinopenic T2D showed severe glucose intolerance and less BMAT expansion, indicating differing impacts on bone health between the conditions.
The Human Footprint and Climate Change Shape Current and Future Scenarios of Visceral Leishmaniasis Distribution in Doce River Basin in Brazil.
Am J Trop Med Hyg
December 2024
Graduate Program in Biological Sciences, Center for Research in Biological Sciences, Federal University of Ouro Preto, Ouro Preto, Brazil.
Article Synopsis
- The study investigates how environmental and climate factors affect the spread of visceral leishmaniasis (VL) in Brazil's Doce River basin, aiming to enhance future surveillance and control efforts.
- It utilizes ecological niche modeling, analyzing 855 VL cases from 2001-2018 to predict current and future disease distributions based on various climatic and environmental variables.
- Key findings indicate that human activities and climate change could increase VL suitable areas by 7% by 2041 and 12% by 2080, emphasizing the need for improved vector control initiatives in the region.
PRIO - a prospective integrative oncology registry: trial protocol.
Front Oncol
December 2024
Research Group Integrative Medicine, Department of General and Visceral Surgery, University Hospital Ulm, Ulm, Germany.
Background: Integrative Oncology (IO) - the use of lifestyle modifications, mind-body practices and natural products in oncology - is increasingly asked for by patients. The evidence base of IO is growing and IO measures are included in national guidelines. Still, many questions about IO remain unanswered or still show a poor evidence base.
View Article and Find Full Text PDFPhase I clinical trial testing the dose escalation and expansion of Pressurized IntraThoracic Hyperthermic Aerosol Cisplatin administration (PITHAC) for the management of pleural carcinosis.
Cancer Treat Res Commun
December 2024
Division of Thoracic Surgery, University Hospital of Lausanne, Rue du Bugnon 46 1011, Lausanne, Switzerland. Electronic address:
Background: Pleural carcinosis originates from various cancers. Its management consists in systemic therapies combined to dyspnea relief procedures. Prior studies have tested hyperthermic intrathoracic chemotherapy to treat pleural carcinosis with interesting patient survival results.
View Article and Find Full Text PDFThe prognosis and treatment consideration for non-small cell lung carcinoma patients with tumor size of >2.0-3.0 cm and visceral pleural invasion: a SEER-based study.
Transl Cancer Res
November 2024
Department of Thoracic Surgery, The First Affiliated Hospital of Shantou University Medical College, Shantou, China.
Background: Lung cancer is the most prevailing oncological disease worldwide. Visceral pleural invasion (VPI) has been proven to be a poor prognosis factor for early-stage non-small cell lung carcinoma (NSCLC) patients. However, there remains some debate regarding whether NSCLC patients with tumor size (TS) ranging from >2.
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