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Relevance of reporting leprosy related disability at the completion of multi drug therapy: A 5-year retrospective analysis of disability in persons affected by leprosy at ALERT Hospital Ethiopia.
PLoS Negl Trop Dis
December 2024
Department of Internal Medicine, Addis Ababa University, Addis Ababa, Ethiopia.
Background: Leprosy is one of the neglected tropical diseases associated with significant morbidity in endemic regions. It causes disability affecting the daily activities and social participation of affected individuals. Understanding the prevalence and trend of leprosy-related disability throughout the world and the accuracy of disability data counted by WHO is crucial in guiding efforts to be made towards the targets set by WHO to be achieved by 2030.
View Article and Find Full Text PDFLucio Phenomenon: a Review.
Am J Dermatopathol
January 2025
Service of Dermatology "Dr. Mario Magaña Lozano' of the Hospital General de México "Dr. Eduardo Liceaga', S.S. (Ministry of Health)/Faculty of Medicine, Universidad Nacional Autónoma de México (UNAM), Mexico City, México.
Mycobacterium leprae and M. lepromatosis, the causative agents of leprosy, have left a mark on human history. Despite advances in health care, leprosy continues to affect millions worldwide, often leading to complications, mostly neural, due to delayed diagnosis and treatment.
View Article and Find Full Text PDFPreVenTB trial: protocol for evaluation of efficacy and safety of two vaccines VPM1002 and Immuvac (Mw) in preventing tuberculosis (TB) in healthy household contacts of newly diagnosed sputum smear-positive pulmonary TB patients: phase III, randomised, double-blind, three-arm placebo-controlled trial.
BMJ Open
August 2024
Division of HIV/AIDS, World Health Organization, Geneva, Switzerland.
Introduction: Tuberculosis (TB) continues to be one of the deadliest infectious diseases over the centuries, killing more people worldwide than any other single infectious disease. There is an urgent need for additional strategies which can expedite efforts to combat TB including a preventive vaccine. In this endeavour, we have developed a protocol for a multisite, double-blind, placebo-controlled clinical trial in India that aims to evaluate the efficacy and safety of two TB vaccines; namely, VPM1002 and Immuvac () () (MIP) among healthy household contacts (HHCs) of sputum smear-positive pulmonary TB (PTB) patients.
View Article and Find Full Text PDFRapid test for Mycobacterium leprae infection: a practical tool for leprosy.
Infect Dis Poverty
December 2024
Leiden University Center of Infectious Diseases, Leiden University Medical Center, Leiden, The Netherlands.
Background: Detection of infection with Mycobacterium leprae allows timely prophylactic treatment, thereby reducing transmission as well as the risk of permanent, leprosy-associated nerve damage. However, since there is no worldwide-implemented standard test for M. leprae infection, detection of infection in asymptomatic individuals remains a major challenge for control programs in endemic areas.
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