AI Article Synopsis
- Host actin cytoskeleton polymerization is crucial for the internalization of the parasite Trypanosoma cruzi into mammalian cells.
- Researchers investigated the role of the actin-binding protein AFAP-1L1 and found that reducing its levels led to increased invasion and multiplication of T. cruzi.
- The study concludes that AFAP-1L1 is vital for maintaining actin cytoskeleton integrity, thereby helping to limit parasite infection.
Article Abstract
Host actin cytoskeleton polymerization has been shown to play an important role during Trypanosoma cruzi internalization into mammalian cell. The structure and dynamics of the actin cytoskeleton in cells are regulated by a vast number of actin-binding proteins. Here we aimed to verify the impact of AFAP-1L1, during invasion and multiplication of T. cruzi. Knocking-down AFAP-1L1 increased parasite cell invasion and intracellular multiplication. Thus, we have shown that the integrity of the machinery formed by AFAP-1L1 in actin cytoskeleton polymerization is important to hinder parasite infection.
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| http://dx.doi.org/10.1016/j.actatropica.2016.06.028 | DOI Listing |
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